Severe COVID-19 infection associated with endothelial dysfunction induces multiple organ dysfunction: a review of therapeutic interventions

Y Matsuishi, BJ Mathis, N Shimojo, J Subrina, N Okubo… - Biomedicines, 2021 - mdpi.com
Since December 2019, the SARS-CoV-2 (COVID-19) pandemic has transfixed the medical
world. COVID-19 symptoms vary from mild to severe and underlying chronic conditions such …

Endothelial dysfunction and COVID‑19

J Daher - Biomedical Reports, 2021 - spandidos-publications.com
It is hypothesized that several comorbidities increase the severity of COVID‑19 symptoms.
Cardiovascular disease including hypertension was shown to play a critical role in the …

Role of endothelium in cardiovascular sequelae of long COVID

L Santoro, V Zaccone, L Falsetti, V Ruggieri, M Danese… - Biomedicines, 2023 - mdpi.com
The global action against coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2
infection, shed light on endothelial dysfunction. Although SARS-CoV-2 primarily affects the …

Endothelial dysfunction and SARS-CoV-2 infection: association and therapeutic strategies

H Deng, TX Tang, D Chen, LS Tang, XP Yang… - Pathogens, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-
coronavirus 2 (SARS-CoV-2), has been recently considered a systemic disorder leading to …

Vascular endothelial damage in the pathogenesis of organ injury in severe COVID-19

A Dupont, A Rauch, S Staessens… - … and Vascular Biology, 2021 - Am Heart Assoc
Objective: Whether endotheliopathy only mirrors coronavirus disease 2019 (COVID-19)
severity or plays an intrinsic role in microvascular thrombosis and organ failure remains …

[HTML][HTML] Endothelial dysfunction in COVID-19: Current findings and therapeutic implications

MP Nägele, B Haubner, FC Tanner, F Ruschitzka… - Atherosclerosis, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) increases the risk of several non-pulmonary
complications such as acute myocardial injury, renal failure or thromboembolic events. A …

[HTML][HTML] Endothelial contribution to COVID-19: an update on mechanisms and therapeutic implications

Z Ma, KY Yang, Y Huang, KO Lui - Journal of Molecular and Cellular …, 2022 - Elsevier
The global propagation of SARS-CoV-2 leads to an unprecedented public health
emergency. Despite that the lungs are the primary organ targeted by COVID-19, systemic …

Role of endothelial dysfunction in the severity of COVID‑19 infection

T Kadiyska, I Tourtourikov… - Molecular …, 2022 - spandidos-publications.com
COVID‑19 patients with severe infection have been observed to have elevated auto‑
antibodies (AAs) against angiotensin II receptor type 1 (AT1R) and endothelin (ET) 1 …

[HTML][HTML] Acute and chronic cardiovascular manifestations of COVID-19: role for endotheliopathy

JP Cooke, JH Connor, A Jain - Methodist DeBakey Cardiovascular …, 2021 - ncbi.nlm.nih.gov
Abstract SARS-CoV-2, the virus that causes coronavirus disease 19 (COVID-19), is
associated with a bewildering array of cardiovascular manifestations, including myocardial …

Is the endothelium the missing link in the pathophysiology and treatment of COVID-19 complications?

P Castro, M Palomo, AB Moreno-Castaño… - … drugs and therapy, 2022 - Springer
Patients with COVID-19 present a wide spectrum of disease severity, from asymptomatic
cases in the majority to serious disease leading to critical care and even death. Clinically …