A Phase I, Dose-Escalation Clinical Trial to Evaluate the Safety of Infusing Natural Killer Cells as Adoptive Therapy in COVID-19: Release

C Hernández-Blanco, K Al-Akioui-Sanz… - papers.ssrn.com
Background: The severity of COVID 19 symptoms has a direct correlation with lymhpopenia,
affecting natural killer (NK) cells. SARS-CoV-2 specific “memory” NK cells obtained from …

[HTML][HTML] A Phase I/II Dose-Escalation Multi-Center Study to Evaluate the Safety of Infusion of Natural Killer Cells or Memory T Cells As Adoptive Therapy in …

A Pérez-Martínez, A Martín-Quirós, C Ferreras… - Blood, 2021 - Elsevier
Background: Adoptive cell immunotherapies for opportunistic virus in immunocompromised
patients using haploidentical memory T cells have shown to be safe and effective. Since …

A phase I/II dose-escalation multi-center study to evaluate the safety of infusion of natural killer cells or memory T cells as adoptive therapy in coronavirus pneumonia …

I García-García, P Guerra-García, C Ferreras… - Trials, 2021 - Springer
Background Moderate/severe cases of COVID-19 present a dysregulated immune system
with T cell lymphopenia and a hyper-inflammatory state. This is a study protocol of an open …

Identifying SARS‐CoV‐2 'memory'NK cells from COVID‐19 convalescent donors for adoptive cell therapy

L Herrera, M Martin‐Inaraja, S Santos… - …, 2022 - Wiley Online Library
COVID‐19 disease is the manifestation of syndrome coronavirus 2 (SARS‐CoV‐2) infection,
which is causing a worldwide pandemic. This disease can lead to multiple and different …

Exhausted NK cells and cytokine storms in COVID-19: Whether NK cell therapy could be a therapeutic choice

M Ghasemzadeh, A Ghasemzadeh, E Hosseini - Human immunology, 2022 - Elsevier
The global outbreak of coronavirus-2019 (COVID-19) still claims more lives daily around the
world due to the lack of a definitive treatment and the rapid tendency of virus to mutate …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

[HTML][HTML] The promise and peril of natural killer cell therapies in pulmonary infection

S Rajaram, LM Canaday, DE Ochayon, KM Rangel… - Immunity, 2020 - cell.com
The emergence of novel respiratory viruses such as SARS-CoV-2 results in rapid
dissemination through virus-naive populations and an accumulation of critically ill patients in …

Natural killer cell exhaustion in SARS-CoV-2 infection

J Gallardo-Zapata, C Maldonado-Bernal - Innate Immunity, 2022 - journals.sagepub.com
At the end of 2019, an outbreak of a severe respiratory disease occurred in Wuhan China,
and an increase in cases of unknown pneumonia was alerted. In January 2020, a new …

NK cells in COVID-19: protectors or opponents?

A Alrubayyi - Nature Reviews Immunology, 2020 - nature.com
Natural killer (NK) cells contribute to early antiviral immunity, and in this preprint,
Maucourant et al. report reduced NK cell counts in the peripheral blood of 27 patients …

Natural killer cells associated with SARS-CoV-2 viral RNA shedding, antibody response and mortality in COVID-19 patients

C Bao, X Tao, W Cui, Y Hao, S Zheng, B Yi… - … hematology & oncology, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Two consecutively …