There is now considerable evidence suggesting that the plasma membrane of mammalian
cells is compartmentalized by functional lipid raft microdomains. These structures are …

The molecular events and the protein components that are involved in signalling by the T
cell receptor (TCR) for antigen have been extensively studied. Activation of signalling …

Detergent‐resistant membrane microdomains enriched in sphingolipids, cholesterol and
glycosylphosphatidylinositol‐anchored proteins play essential roles in T cell receptor (TCR) …

Membrane microdomains denoted commonly as lipid rafts (or membrane rafts) have been
implicated in T-cell receptor (TCR), and more generally immunoreceptor, signaling for over …

Copyright 2000 Academic PressPlasma membranes of many cell types contain domains
enriched in specific lipids and cholesterol, called lipid rafts. In T lymphocytes, key T cell …

Lateral mobility and spatial organization of proteins within the plasma membrane are likely
to mediate the initial events coordinating T cell activation. Lipid rafts, distinct cholesterol …

Membrane rafts and signaling molecules associated with them are thought to play important
roles in immunoreceptor signaling. Rafts differ in their lipid and protein compositions from …

A key question in understanding the functional role of lipid rafts is whether lipid
microdomains at the plasma membrane outer leaflet are coupled to lipid microdomains at …

Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological
responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as …

Raft microdomains have been shown to play a key role in T cell activation. We found that in
human T lymphocytes the formation of functional rafts at the plasma membrane was induced …