Covalent modifications of histone tails have a key role in regulating chromatin structure and
controlling transcriptional activity. In eukaryotes, histone H3 trimethylated at lysine 4 …

The inhibitors of growth (ING) family of tumor suppressors consists of five homologous
proteins involved in chromatin remodeling. They form part of different acetylation and …

Chromatin dynamics regulates diverse nuclear processes and influences cellular viability
and tumorigenesis. The discrete chromatin states are linked to covalent histone …

Dynamic regulation of diverse nuclear processes is intimately linked to covalent
modifications of chromatin,. Much attention has focused on methylation at lysine 4 of histone …

Inhibitor of growth 1 (ING1) is implicated in oncogenesis, DNA damage repair, and
apoptosis. Mutations within the ING1 gene and altered expression levels of ING1 are found …

The Inhibitor of Growth (ING) tumor suppressors are implicated in oncogenesis, control of
DNA damage repair, cellular senescence and apoptosis. All members of the ING family …

In yeast and animals, tri‐and dimethylation of histone H3 at lysine 4 (H3K4me3/2) are
markers of transcriptionally active genes that have recently been shown to be primary …

ING proteins interact with core histones through their plant homeodomains (PHDs),,, and
with histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes to alter …

Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively
little is known of the molecular mechanisms linking histone lysine methylation to neoplastic …

Since the discovery of ING1 class II tumor suppressors in 1996, five different ING genes
(ING1 to ING5) encoding proteins with highly conserved plant homeodomain (PHD) motifs …