Abstract N 6-isopentenyladenosine (i 6 A), a naturally occurring modified nucleoside,
inhibits the proliferation of human tumor cell lines in vitro, but its mechanism of action …

Abstract Aims: The NF-E2 p45-related factor 2 (Nrf2) signaling pathway regulates the
cellular antioxidant response and activation of Nrf2 has recently been shown to limit tissue …

Natural products with antioxidant and anti-inflammatory properties are important sources of
therapeutic agents. The nuclear factor E2-related factor 2 (Nrf2)/antioxidant response …

The induction of NF-E2-related factor-2 (Nrf2)-mediated detoxifying/antioxidant enzymes is
recognized as an effective strategy for cancer chemoprevention. Here, we report that 3 …

The induction of Nrf2-mediated detoxifying/antioxidant enzymes is recognized as an
effective strategy for cancer chemoprevention. Here, we report that 3-morpholinopropyl …

The isothiocyanate sulforaphane (SFN) has been shown to induce phase 2 and antioxidant
enzymes in cultured cells and in vivo via a Nrf2 dependent signal transduction pathway …

NRF2 serves as the master regulator of oxidative stress resistance in mammalian cells.
Although NRF2 activation decreases tumorigenic events in normal cells, accumulating …

Background/Aims: Increased production of multiple pro-inflammatory cytokines, including
tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, plays an essential pathogenic …

Objective This study was conducted to evaluate the effect of the synthetic water-soluble
phenolic antioxidant TS-13 (sodium 3-(4′-methoxyphenyl) propyl thiosulfonate), an inducer …

The Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating a
wide array of genes for antioxidant and detoxification enzymes in response to oxidative and …