Denervation alters the metabolism of the extracellular matrix (ECM) in skeletal muscle;
however, the underlying mechanisms of ECM remodeling are not fully understood. The aim …

Our understanding of the effects of long-term denervation on skeletal muscle is heavily
influenced by an extensive literature based on the rat. We have studied physiological and …

The activities of prolyl 4-hydroxylase (PH) and galactosylhydroxylysyl glucosyltransferase
(GGT), both enzymes of collagen biosynthesis, and the concentration of hydroxyproline …

Denervation or inactivity is known to decrease the mass and alter the phenotype of muscle
and the mechanics of tendon. It has been proposed that a shift in the collagen of the …

Cellular proliferation in skeletal muscle was measured throughout the first 4 weeks after
denervation. Twenty four mice had one leg denervated, and 4 groups of 6 of these mice …

Muscular fibrosis is caused by excessive accumulation of extracellular matrix (ECM) that
replaces functional tissue, and it is a feature of several myopathies and neuropathies …

Objective: To evaluate the effects of electrical stimulation (ES), stretching and their combined
effects in matrix metalloproteinases (MMPs) gene expression and activity during early …

Background This study describes the ultrastructure of long‐term denervated rat extensor
digitorum longus and tibialis anterior muscles, with particular emphasis on understanding …

Denervation elicits profound alterations in the morphometry of skeletal muscle. These
alterations include changes in fiber type composition as well as reductions in fiber size …

There are many striking similarities in the reactions of mammalian skeletal muscle to
denervation and the normal aging process. In both cases, the tissue environment is far more …