Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor

NL Puskar, HA Lester, DA Dougherty - ACS chemical biology, 2012 - ACS Publications
The nicotinic acetylcholine receptors (nAChRs) are a family of closely related but
pharmacologically distinct neurotransmitter-gated ion channels. They are therapeutic targets …

The wonderland of neuronal nicotinic acetylcholine receptors

D Bertrand, AV Terry Jr - Biochemical pharmacology, 2018 - Elsevier
Nearly 30 years of experimental evidence supports the argument that ligands of nicotinic
acetylcholine receptors (nAChRs) have potential as therapeutic agents. However, as in the …

Characterization of binding site interactions and selectivity principles in the α3β4 nicotinic acetylcholine receptor

HJ Knox, H Rego Campello, HA Lester… - Journal of the …, 2022 - ACS Publications
Nicotinic acetylcholine receptors (nAChRs) play an important role in neurotransmission and
are also involved in addiction and several disease states. There is significant interest in …

Allosteric modulation of nicotinic acetylcholine receptors

A Chatzidaki, NS Millar - Biochemical pharmacology, 2015 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) are receptors for the neurotransmitter
acetylcholine and are members of the 'Cys-loop'family of pentameric ligand-gated ion …

Structural aspects of high affinity ligands for the α4β2 neuronal nicotinic receptor

MJ Dart, JT Wasicak, KB Ryther, MR Schrimpf… - Pharmacochemistry …, 2000 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of related
ion channels that are widely distributed throughout the central and peripheral nervous …

A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor

AP Hanek, HA Lester… - Journal of the American …, 2008 - ACS Publications
Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and
similar channels constitutes a significant challenge in chemical neurobiology. In the present …

Diversity of native nicotinic receptor subtypes in mammalian brain

M Zoli, F Pistillo, C Gotti - Neuropharmacology, 2015 - Elsevier
Neuronal nicotinic acetylcholine receptors (nAChRs) are a heterogeneous family of
pentameric ligand-gated cation channels that are expressed throughout the brain and …

Naturally-expressed nicotinic acetylcholine receptor subtypes

J Wu, RJ Lukas - Biochemical pharmacology, 2011 - Elsevier
Nicotinic acetylcholine receptors (nAChRs) warrant attention, as they play many critical roles
in brain and body function and have been implicated in a number of neurological and …

Nicotinic receptors, allosteric proteins and medicine

JP Changeux, A Taly - Trends in molecular medicine, 2008 - cell.com
The nicotinic acetylcholine receptor (nAChR) was the first ion channel and membrane
receptor of a neurotransmitter to be isolated and chemically identified and is one of the best …

Recent advances in understanding the structure of nicotinic acetylcholine receptors

M Zouridakis, P Zisimopoulou, K Poulas… - IUBMB life, 2009 - Wiley Online Library
Nicotinic acetylcholine receptors (nAChRs), members of the Cys‐loop ligand‐gated ion
channels (LGICs) superfamily, are involved in signal transduction upon binding of the …