A computer-based algorithm was used to cluster the loops forming the complementarity
determining region (CDR) 3 of the heavy chain (H3) into canonical classes. Previous …

The structure of the most variable antibody hypervariable loop, CDR-H3, has been predicted
from amino acid sequence alone. In contrast to other approaches predictions are made for …

The third complementary determining region of the immunoglobulin heavy chain (CDR H3)
is one of the more difficult structures to model due to genetic reasons. However, the …

Previous analyses of the complementarity-determining regions (CDRs) of antibodies have
focused on a small number of “canonical” conformations for each loop. This is primarily the …

Motivation: Antibodies are able to recognize a wide range of antigens through their
complementary determining regions formed by six hypervariable loops. Predicting the 3D …

Loop regions of polypeptide in homologous proteins may be classified into structural
families. A method is described by which this classification may be performed automatically …

Antibodies have the capability of binding a wide range of antigens due to the diversity of the
six loops constituting the complementarity determining region (CDR). Among the six loops …

Antibodies are used extensively in medical and biological research. Their complementarity
determining regions (CDRs) define the majority of their antigen binding functionality. CDR …

Predicting the structure of the antibody variable region from sequence has been the focus of
considerable research since the work of Kabat and Wu (1), Padlan et al.(2), Stanford and Wu …

Grafting the antigen-binding loops onto a human antibody scaffold is a widely used
technique to humanise murine antibodies. The success of this approach depends largely on …