Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …

Membrane transporters play an important role in intestinal absorption, distribution and
clearance of drugs. Additionally transporters along with enzymes regulate tissue exposures …

Recent analyses demonstrated that metabolites are unlikely to contribute significantly to
clinical inhibition of cytochrome P450 (P450)–mediated drug metabolism, and that only∼ …

The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …

Pharmacokinetic drug-drug interactions (DDIs) are a major concern in drug development.
Drug transport, along with drug metabolism via cytochrome P450s (CYPs), is increasingly …

Introduction Transporters are significant in dictating drug pharmacokinetics, thus inhibition of
transporter function can alter drug concentrations resulting in drug-drug interactions (DDIs) …

High-permeability–low-molecular-weight acids/zwitterions [ie, extended clearance
classification system class 1A (ECCS 1A) drugs] are considered to be cleared by …

At present, many patients are medicated with various drugs, which are, at the same time,
associated with an increased risk of drug–drug interactions (DDIs). Detailed analysis of …

Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …

Drug–drug interactions are a major concern not only during clinical practice, but also in drug
development. Due to limitations of in vitro–in vivo predictions of transporter-mediated drug …