Quantitative prediction of drug‐drug interactions (DDIs) involving organic anion transporting
polypeptide (OATP) 1B1/1B3 inhibition is limited by uncertainty in the translatability of …

Transporters play an important role in drug absorption, disposition, and drug action. The
evaluation of drug transporters requires a comprehensive understanding of transporter …

Background: Hepatic drug transporters of the solute carrier (OATPs, OAT2, OCT1, NTCP)
and ABC transporter superfamilies (MDR1, MRPs, BCRP, BSEP) can significantly modulate …

For successful in vitro-to-in vivo extrapolation of hepatic drug uptake and drug-drug
interactions (DDI), it is important to characterize the kinetic properties of the individual …

Introduction: Membrane transporters of the SLC and ABC families are abundantly expressed
in the liver, where they control the transfer of drugs/drug metabolites across the sinusoidal …

This white paper addresses current approaches and knowledge gaps concerning methods
to assess the role of transport proteins in drug/metabolite disposition in humans. The …

We have seen an increased use of computational approaches to predicting drug interactions
with human transporters that affect drug disposition and may lead to toxicity. These …

This review provides a practical clinical perspective on the relevance of hepatic transporters
in pharmacokinetics and drug‐drug interactions (DDIs). Special emphasis is placed on …

Introduction: The key role of transporter biology in both the manifestation and treatment of
disease is now firmly established. Experiences of sub-optimal drug exposure due to drug …

Drug transporters are widely expressed in organs and tissue barriers throughout human and
animal bodies. Studies over the last two decades have identified various ATP-binding …