Predicting transporter-based drug clearance (CL) and tissue concentrations (TC) in humans
is important to reduce the risk of failure during drug development. In addition, when …

The organic anion transporting protein 1B3 (OATP1B3), formerly termed OATP8, is
responsible for uptake and subsequent elimination of multiple amphipathic drugs by the …

Membrane transporters have been recognized as one of the key determinants of
pharmacokinetics and are also known to affect the efficacy and toxicity of drugs. Both …

With efforts to reduce cytochrome P450-mediated clearance (CL) during the early stages of
drug discovery, transporter-mediated CL mechanisms are becoming more prevalent …

Nobody doubts the importance of organic anion transporting polypeptide (OATP) 1B1 and
1B3 in the clinical pharmacokinetics of substrate drugs. Based on the theory of …

Drug-metabolizing enzymes and transporters (DMETs) are key regulators of the
pharmacokinetics, efficacy, and toxicity of therapeutics. Over the past two decades …

▪ Abstract Recent studies have revealed the import role played by transporters in the renal
and hepatobiliary excretion of many drugs. These transporters exhibit a broad substrate …

Introduction: Drug transporters play an important role in the absorption, distribution, and
excretion (ADE) of many drugs. In the last several years it has become increasingly clear …

The use of in vitro data for quantitative predictions of transporter-mediated elimination in vivo
requires an accurate estimation of the transporter Michaelis-Menten parameters, V max and …

Comprehensive characterization of transporter mediated drug‐drug interactions (DDIs) is
important to formulate clinical management strategies and ensure the safe and effective use …