Clinical implications of altered drug transporter abundance/function and PBPK modeling in specific populations: an ITC perspective
The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …
Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug–drug interaction to support regulatory submissions
P Sharma, VE Holmes, R Elsby, C Lambert, D Surry - Xenobiotica, 2010 - Taylor & Francis
Transporters are carrier proteins that may influence pharmacokinetic, pharmacodynamic,
and toxicological characteristics of drugs. The development of validated in vitro transporter …
and toxicological characteristics of drugs. The development of validated in vitro transporter …
Progress in the Quantitative Assessment of Transporter-Mediated Drug–Drug Interactions Using Endogenous Substrates in Clinical Studies
T Mochizuki, H Kusuhara - Drug Metabolism and Disposition, 2023 - ASPET
Variations in drug transporter activities, caused by genetic polymorphism and drug–drug
interactions (DDIs), alter the systemic exposure of substrate drugs, leading to differences in …
interactions (DDIs), alter the systemic exposure of substrate drugs, leading to differences in …
Regulation of drug transport proteins—From mechanisms to clinical impact: A white paper on behalf of the international transporter consortium
Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …
Clinical importance of OATP1B1 and OATP1B3 in drug–drug interactions
Y Shitara - Drug metabolism and pharmacokinetics, 2011 - jstage.jst.go.jp
OATP1B1 and OATP1B3 are transporters that are expressed on the sinusoidal membrane of
hepatocytes; they accept a number of therapeutic reagents as their substrates. In vitro and in …
hepatocytes; they accept a number of therapeutic reagents as their substrates. In vitro and in …
In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein
K Howe, GG Gibson, T Coleman, N Plant - Drug Metabolism and Disposition, 2009 - ASPET
The impact of transport proteins in the disposition of chemicals is becoming increasingly
evident. Alteration in disposition can cause altered pharmacokinetic and pharmacodynamic …
evident. Alteration in disposition can cause altered pharmacokinetic and pharmacodynamic …
Evaluation and quantitative prediction of renal transporter‐mediated drug‐drug interactions
B Feng, MV Varma - The Journal of Clinical Pharmacology, 2016 - Wiley Online Library
With numerous drugs cleared renally, inhibition of uptake transporters localized on the
basolateral membrane of renal proximal tubule cells, eg, organic anion transporters (OATs) …
basolateral membrane of renal proximal tubule cells, eg, organic anion transporters (OATs) …
In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney
H Kusuhara, Y Sugiyama - Drug metabolism and pharmacokinetics, 2009 - jstage.jst.go.jp
Transporters govern drug movement into and out of tissues, thereby playing an important
role in drug disposition in plasma and to the site of action. The molecular cloning of such …
role in drug disposition in plasma and to the site of action. The molecular cloning of such …
Role of Oatp2b1 in drug absorption and drug-drug interactions
The organic anion transporting polypeptide (OATP) 2B1 is localized on the basolateral
membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern …
membrane of hepatocytes and is expressed in enterocytes. Based on its distribution pattern …
Future directions for drug transporter modelling
Since the late 1980s computational methods such as quantitative structure–activity
relationship (QSAR) and pharmacophore approaches have become more widely applied to …
relationship (QSAR) and pharmacophore approaches have become more widely applied to …