Motivation Single-cell RNA-sequencing (scRNA-seq) allows whole transcriptome profiling of thousands of individual cells, enabling the molecular exploration of tissues at the cellular …
Single-cell RNA-sequencing (scRNAseq) technologies are rapidly evolving. Although very informative, in standard scRNAseq experiments, the spatial organization of the cells in the …
Spatial genomics technologies enable new approaches to study how cells interact and function in intact multicellular environments but present a host of technical and …
Motivation In recent years we have witnessed an increase in novel RNA-seq based techniques for transcriptomics analysis. Spatial transcriptomics is a novel RNA-seq based …
Z Xu, W Wang, T Yang, J Chen, Y Huang, J Gould… - bioRxiv, 2022 - biorxiv.org
Recent technological development in spatial transcriptomics allows researchers to measure gene expression of cells and their spatial locations at the almost single-cell level, which …
Spatial transcriptomics and single cell RNA-sequencing offer complementary insights into the transcriptional expression landscape. We here present a probabilistic method that …
Sequencing-based spatial transcriptomics (ST) methods allow unbiased capturing of RNA molecules at barcoded spots, charting the distribution and localization of cell types and …
J Qian, J Liao, Z Liu, Y Chi, Y Fang, Y Zheng… - Nature …, 2023 - nature.com
Tissues are highly complicated with spatial heterogeneity in gene expression. However, the cutting-edge single-cell RNA-seq technology eliminates the spatial information of individual …