T Noel, QS Wang, A Greka, JL Marshall - Frontiers in Physiology, 2022 - frontiersin.org
Spatial transcriptomic technologies capture genome-wide readouts across biological tissue space. Moreover, recent advances in this technology, including Slide-seqV2, have achieved …
Recent technological advances have enabled spatially resolved measurements of expression profiles for hundreds to thousands of genes in fixed tissues at single-cell …
Spatial transcriptomics (ST) technology, providing spatially resolved transcriptional profiles, facilitates advanced understanding of key biological processes related to health and …
CK Mah, N Ahmed, NA Lopez, DC Lam, A Pong… - Genome Biology, 2024 - Springer
The spatial organization of molecules in a cell is essential for their functions. While current methods focus on discerning tissue architecture, cell–cell interactions, and spatial …
Cellular function in tissue is dependent upon the local environment, requiring new methods for spatial mapping of biomolecules and cells in the tissue context. The emergence of spatial …
T Li, D Horsfall, D Basurto-Lozada, K Roberts, M Prete… - bioRxiv, 2023 - biorxiv.org
Single cell and spatial transcriptomics illuminate complementary features of tissues. However, online dissemination and exploration of integrated datasets is challenging due to …
A limitation of spatial transcriptomics technologies is that individual measurements may contain contributions from multiple cells, hindering the discovery of cell-type-specific spatial …
Single-cell RNA-seq (scRNA-seq) is widely used to investigate the composition of complex tissues–since the technology allows researchers to define cell-types using unsupervised …
J He, C Deng, L Krall, Z Shan - Cell Regeneration, 2023 - Springer
Spatial transcriptomics, which combine gene expression data with spatial information, has quickly expanded in recent years. With application of this method in liver research, our …