Nutrients and pathways that regulate health span and life span

C Pignatti, S D'Adamo, C Stefanelli, F Flamigni… - Geriatrics, 2020 - mdpi.com
Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

[HTML][HTML] Macronutrients and caloric intake in health and longevity

SM Solon-Biet, SJ Mitchell, R de Cabo… - The Journal of …, 2015 - ncbi.nlm.nih.gov
Both lifespan and healthspan are influenced by nutrition, with nutritional interventions
proving to be robust across a wide range of species. However, the relationship between …

Extending healthy ageing: nutrient sensitive pathway and centenarian population

S Davinelli, DC Willcox, G Scapagnini - Immunity & Ageing, 2012 - Springer
Ageing is a challenge for any living organism and human longevity is a complex phenotype.
With increasing life expectancy, maintaining long-term health, functionality and well-being …

[HTML][HTML] Nutrition, longevity and disease: From molecular mechanisms to interventions

VD Longo, RM Anderson - Cell, 2022 - cell.com
Diet as a whole, encompassing food composition, calorie intake, and the length and
frequency of fasting periods, affects the time span in which health and functional capacity …

Effects of nutritional components on aging

D Lee, W Hwang, M Artan, DE Jeong, SJ Lee - Aging cell, 2015 - Wiley Online Library
Nutrients including carbohydrates, proteins, lipids, vitamins, and minerals regulate various
physiological processes and are essential for the survival of organisms. Reduced overall …

Death and dessert: nutrient signalling pathways and ageing

N Alic, L Partridge - Current opinion in cell biology, 2011 - Elsevier
Reduction in nutrient intake without malnutrition can delay ageing and extend healthy life in
diverse organisms from yeast to primates. This effect can be recapitulated by genetic or …

Nutrigerontology: a key for achieving successful ageing and longevity

A Aiello, G Accardi, G Candore, G Carruba… - Immunity & …, 2016 - Springer
During the last two centuries the average lifespan has increased at a rate of approximately 3
months/year in both sexes, hence oldest old people are becoming the population with the …

Dietary restriction and nutrient balance in aging

J Santos, F Leitão-Correia, MJ Sousa… - Oxidative Medicine and …, 2016 - Wiley Online Library
Dietary regimens that favour reduced calorie intake delay aging and age‐associated
diseases. New evidences revealed that nutritional balance of dietary components without …

Regulation of metabolic health and aging by nutrient-sensitive signaling pathways

NE Cummings, DW Lamming - Molecular and cellular endocrinology, 2017 - Elsevier
All organisms need to be capable of adapting to changes in the availability and composition
of nutrients. Over 75 years ago, researchers discovered that a calorie restricted (CR) diet …

Dietary supplements and natural products: an update on their clinical effectiveness and molecular mechanisms of action during accelerated biological aging

Y Chen, S Hamidu, X Yang, Y Yan, Q Wang, L Li… - Frontiers in …, 2022 - frontiersin.org
Accelerated biological aging, which involves the gradual decline of organ or tissue functions
and the distortion of physiological processes, underlies several human diseases. Away from …