The retinoblastoma protein, Rb, is encoded by a classic tumor suppressor gene that is
mutated in a large variety of tumors. Extensive studies have suggested that Rb functions as …

Rb was the first tumour suppressor identified through human genetic studies. The most
significant achievement after almost twenty years since its cloning is the revelation that Rb …

The retinoblastoma protein (RB)-mediated regulation of E2F is a component of a highly
conserved cell cycle machine. However, RB's tumor suppressor activity, like RB's …

The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the
transcription of cellular genes required for DNA replication and cell division. Recent …

In cancer cells, the retinoblastoma tumor suppressor RB is directly inactivated by mutation in
the RB gene or functionally inhibited by abnormal activation of cyclin-dependent kinase …

The retinoblastoma protein (Rb) is a tumor suppressor that regulates progression from the
G1 phase to the S phase of the cell cycle. Previously, we found that Rb is a transcriptional …

The retinoblastoma gene product is an abundant nuclear protein whose 'pocket
domain'mediates numerous protein–protein interactions. A substantial proportion of the RB …

The retinoblastoma (RB) gene is the prototype tumor suppressor gene. It encodes a nuclear
protein that acts as a cell cycle control checkpoint at the G1 phase. Deletion or inactivation of …

The retinoblastoma protein (pRB) can both positively and negatively regulate transcription.
The former correlates with its ability to promote differentiation and the latter with its ability to …

The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well
known as a negative regulator of the cell cycle through its ability to bind the transcription …