Hundreds of viruses cause central nervous system (CNS) disease, including
meningoencephalitis and postinfectious encephalomyelitis, in humans. The cerebrospinal …

The etiology of encephalitis and meningitis, serious diseases of the central nervous system
(CNS), in most cases remains unknown. The importance of establishing a diagnosis …

The use of nucleic acid (NA) amplification techniques has transformed the diagnosis of viral
infections of the central nervous system (CNS). Because of their enhanced sensitivity, these …

Background. Polymerase chain reaction (PCR) is becoming more common in diagnostic
laboratories. In some instances, its value has been established. In other cases, assays exist …

Viral encephalitis causes acute inflammation of the brain parenchyma and is a significant
cause of human morbidity and mortality. Although Herpes Simplex encephalitis is the most …

In this study we have devised a simple and robust PCR strategy to detect a wide range of
viruses, bacteria, and parasites, all of which are capable of causing aseptic meningitis and …

Central nervous system (CNS) infections are potentially life threatening if not diagnosed and
treated early. The initial clinical presentations of many CNS infections are non-specific …

We screened for viral DNA in cerebrospinal fluid samples using next-generation sequencing
(NGS) technology to diagnose CNS viral infections. We collected CSF samples from four …

ABSTRACT A multiplex PCR assay that detects the four commonest causes of viral
meningitis and encephalitis in the United Kingdom (herpes simplex virus [HSV] type 1 [HSV …

Numerous viral pathogens possess the ability to invade the central nervous system (CNS)
and produce neurologic dysfunction (Table 1). Although most infections with neurotropic …