A picky eater: exploring the mechanisms of selective autophagy in human pathologies

A Van Der Vaart, M Mari, F Reggiori - Traffic, 2008 - Wiley Online Library
Autophagy is a catabolic process conserved among all eukaryotes essential for the cellular
and organismal homeostasis. One of the principal roles of this pathway is to maintain an …

Regulation of autophagy by the Rab GTPase network

X Ao, L Zou, Y Wu - Cell Death & Differentiation, 2014 - nature.com
Autophagy (macroautophagy) is a highly conserved intracellular and lysosome-dependent
degradation process in which autophagic substrates are enclosed and degraded by a …

Mechanisms governing autophagosome biogenesis

H Nakatogawa - Nature reviews Molecular cell biology, 2020 - nature.com
Autophagosomes are double-membrane vesicles newly formed during autophagy to engulf
a wide range of intracellular material and transport this autophagic cargo to lysosomes (or …

[HTML][HTML] Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy

V Rogov, V Dötsch, T Johansen, V Kirkin - Molecular cell, 2014 - cell.com
Selective autophagy ensures recognition and removal of various cytosolic cargos. Hence,
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …

Key regulators of autophagosome closure

W Jiang, X Chen, C Ji, W Zhang, J Song, J Li, J Wang - Cells, 2021 - mdpi.com
Autophagy is an evolutionarily conserved pathway, in which cytoplasmic components are
sequestered within double-membrane vesicles called autophagosomes and then …

The role of membrane-trafficking small GTPases in the regulation of autophagy

CF Bento, C Puri, K Moreau… - Journal of cell …, 2013 - journals.biologists.com
Macroautophagy is a bulk degradation process characterised by the formation of double-
membrane vesicles, called autophagosomes, which deliver cytoplasmic substrates for …

Regulation of mammalian autophagy in physiology and pathophysiology

B Ravikumar, S Sarkar, JE Davies… - Physiological …, 2010 - journals.physiology.org
(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Atg29 phosphorylation regulates coordination of the Atg17-Atg31-Atg29 complex with the Atg11 scaffold during autophagy initiation

K Mao, LH Chew, Y Inoue-Aono… - Proceedings of the …, 2013 - National Acad Sciences
Macroautophagy (hereafter autophagy) functions in the nonselective clearance of
cytoplasm. This process participates in many aspects of cell physiology, and is conserved in …

Autophagy in health and disease: From molecular mechanisms to therapeutic target

G Lu, Y Wang, Y Shi, Z Zhang, C Huang, W He… - MedComm, 2022 - Wiley Online Library
Macroautophagy/autophagy is an evolutionally conserved catabolic process in which
cytosolic contents, such as aggregated proteins, dysfunctional organelle, or invading …

[HTML][HTML] Structure biology of selective autophagy receptors

BW Kim, DH Kwon, HK Song - BMB reports, 2016 - ncbi.nlm.nih.gov
Autophagy is a process tightly regulated by various autophagy-related proteins. It is
generally classified into non-selective and selective autophagy. Whereas non-selective …