We developed and characterized a mouse model of elevated intraocular pressure (IOP) to
investigate the underlying cellular and genetic mechanisms of retinal ganglion cell (RGC) …

Purpose To study alterations in different retinal cell types associated with retinal ganglion
cell (RGC) death after elevation of intraocular pressure (IOP) in rats. Methods IOP was …

purpose. The response of retinal ganglion cells (RGCs) to ocular pressure in glaucoma
likely involves signals from astrocytes and microglia. How glia-derived factors influence …

Cellular responses to changes in pressure are implicated in numerous disease processes.
In glaucoma apoptosis of retinal ganglion cells (RGCs) is associated with elevated intra …

We describe a model of acute intraocular pressure (IOP) elevation in the mouse eye that
induces reversible loss of inner retinal function associated with oxidative stress, glial cell …

Purpose. Diabetes mellitus (DM) is a risk factor for open-angle glaucoma, although the
mechanistic interrelationship of the two is debatable. The purpose of this study is to test …

Purpose Elevated intraocular pressure (IOP) is a major risk factor for glaucoma. One
consequence of raised IOP is that ocular tissues are subjected to increased hydrostatic …

Glaucoma is a chronic and progressive optic nerve neuropathy involving the death of retinal
ganglion cells (RGCs). Elevated intraocular pressure (IOP) is considered to be the major risk …

Glaucoma is characterized by loss of retinal ganglion cells (RGCs) and their axons.
Retrograde axoplasmic transport blockade and excitotoxicity were proposed to be a major …

purpose. To characterize a long-term elevated intraocular pressure (IOP) glaucoma model in
the rat with respect to electroretinographic (ERG) changes and the pattern and mechanism …