Single-cell profiling to explore immunological heterogeneity of tumor microenvironment in breast cancer

X Yuan, J Wang, Y Huang, D Shangguan… - Frontiers in …, 2021 - frontiersin.org
Immune infiltrates in the tumor microenvironment (TME) of breast cancer (BRCA) have been
shown to play a critical role in tumorigenesis, progression, invasion, and therapy resistance …

Comprehensive description of the current breast cancer microenvironment advancements via single-cell analysis

X Yan, Y Xie, F Yang, Y Hua, T Zeng, C Sun… - Journal of Experimental …, 2021 - Springer
Breast cancer is a heterogeneous disease with a complex microenvironment consisting of
tumor cells, immune cells, fibroblasts and vascular cells. These cancer-associated cells …

Mapping breast cancer microenvironment through single-cell omics

Z Tan, C Kan, M Sun, F Yang, M Wong… - Frontiers in …, 2022 - frontiersin.org
Breast cancer development and progression rely not only on the proliferation of neoplastic
cells but also on the significant heterogeneity in the surrounding tumor microenvironment. Its …

Single-cell map of diverse immune phenotypes in the breast tumor microenvironment

E Azizi, AJ Carr, G Plitas, AE Cornish, C Konopacki… - Cell, 2018 - cell.com
Knowledge of immune cell phenotypes in the tumor microenvironment is essential for
understanding mechanisms of cancer progression and immunotherapy response. We …

Single-cell and spatial transcriptome analyses revealed cell heterogeneity and immune environment alternations in metastatic axillary lymph nodes in breast cancer

X Mao, D Zhou, K Lin, B Zhang, J Gao, F Ling… - Cancer Immunology …, 2023 - Springer
Background Tumor heterogeneity plays essential roles in developing cancer therapies,
including therapies for breast cancer (BC). In addition, it is also very important to understand …

[HTML][HTML] Data-driven analysis of immune infiltrate in a large cohort of breast cancer and its association with disease progression, ER activity, and genomic complexity

R Dannenfelser, M Nome, A Tahiri, J Ursini-Siegel… - Oncotarget, 2017 - ncbi.nlm.nih.gov
The tumor microenvironment is now widely recognized for its role in tumor progression,
treatment response, and clinical outcome. The intratumoral immunological landscape, in …

Dissecting tumor-immune microenvironment in breast cancer at a spatial and multiplex resolution

E Tzoras, I Zerdes, N Tsiknakis, GC Manikis… - Cancers, 2022 - mdpi.com
Simple Summary The evaluation of breast cancer immune microenvironment has been
increasingly used in clinical practice, either by counting tumor infiltrating lymphocytes or …

Breast cancer heterogeneity through the lens of single-cell analysis and spatial pathologies

N Zhao, JM Rosen - Seminars in cancer biology, 2022 - Elsevier
Breast cancer ecosystems are composed of complex cell types, including tumor, stromal and
immune cells, each of which can assume diverse phenotypes. Both the heterogeneous …

Comprehensive evaluation of methods to assess overall and cell-specific immune infiltrates in breast cancer

I Nederlof, D De Bortoli, Y Bareche, B Nguyen… - Breast cancer …, 2019 - Springer
Background Breast cancer (BC) immune infiltrates play a critical role in tumor progression
and response to treatment. Besides stromal tumor infiltrating lymphocytes (sTILs) which …

A high-dimensional window into the micro-environment of triple negative breast cancer

I Nederlof, HM Horlings, C Curtis, M Kok - Cancers, 2021 - mdpi.com
Simple Summary Triple negative breast cancer (TNBC) shows a substantial level of
genomic, cellular, and phenotypic heterogeneity. While genomic heterogeneity and …