Anxiety-and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: Protective effects of …

PS Brocardo, F Boehme, A Patten, A Cox… - …, 2012 - Elsevier
Prenatal ethanol exposure can damage the developing nervous system, producing long-
lasting impairments in both brain structure and function. In this study we analyzed how …

[HTML][HTML] Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders

F Ehrhart, S Roozen, J Verbeek, G Koek, G Kok… - Molecular …, 2019 - nature.com
Alcohol exposure during pregnancy affects the development of the fetus in various ways and
may lead to Fetal Alcohol Spectrum Disorders (FASD). FASD is one of the leading …

Fetal oxidative stress mechanisms of neurodevelopmental deficits and exacerbation by ethanol and methamphetamine

PG Wells, S Bhatia, DM Drake… - Birth Defects Research …, 2016 - Wiley Online Library
In utero exposure of mouse progeny to alcohol (ethanol, EtOH) and methamphetamine
(METH) causes substantial postnatal neurodevelopmental deficits. One emerging …

Oxidative stress and DNA damage in the mechanism of fetal alcohol spectrum disorders

S Bhatia, DM Drake, L Miller, PG Wells - Birth defects research, 2019 - Wiley Online Library
This review covers molecular mechanisms involving oxidative stress and DNA damage that
may contribute to morphological and functional developmental disorders in animal models …

Neurotoxic effects of alcohol and acetaldehyde during embryonic development

R Da Lee, S Mi An, S Sun Kim… - Journal of Toxicology …, 2005 - Taylor & Francis
Alcohol drinking during pregnancy results in abnormal fetal development, including fetal
alcohol syndrome (FAS) in humans and experimental animals. FAS is characterized by two …

The impact of prenatal ethanol exposure on neuroanatomical and behavioral development in mice

CW Abbott, OO Kozanian, J Kanaan… - Alcoholism: Clinical …, 2016 - Wiley Online Library
Background In utero alcohol, or ethanol (EtOH), exposure produces developmental
abnormalities in the brain of the fetus, which can result in lifelong behavioral abnormalities …

Neuroanatomical and neurophysiological mechanisms involved in central nervous system dysfunctions induced by prenatal alcohol exposure

C Guerri - Alcoholism: Clinical and Experimental Research, 1998 - Wiley Online Library
One of the most severe consequences of maternal ethanol consumption is the damage to
the developing central nervous system, which is manifested by long‐term cognitive and …

[HTML][HTML] Does moderate drinking harm the fetal brain? Insights from animal models

CF Valenzuela, RA Morton, MR Diaz, L Topper - Trends in neurosciences, 2012 - cell.com
Although public health campaigns advise pregnant women to abstain from ethanol, drinking
during pregnancy is pervasive. Here, we highlight recent studies that have clearly …

[HTML][HTML] Glia and neurodevelopment: focus on fetal alcohol spectrum disorders

M Guizzetti, X Zhang, C Goeke, DP Gavin - Frontiers in pediatrics, 2014 - frontiersin.org
During the last 20 years, new and exciting roles for glial cells in brain development have
been described. Moreover, several recent studies implicated glial cells in the pathogenesis …

Magnetic resonance microscopy-based analyses of the neuroanatomical effects of gestational day 9 ethanol exposure in mice

SE Parnell, HT Holloway, SK O'Leary-Moore… - Neurotoxicology and …, 2013 - Elsevier
Animal model-based studies have shown that ethanol exposure during early gestation
induces developmental stage-specific abnormalities of the face and brain. The exposure …