In utero ethanol exposure elicits oxidative stress in the rat fetus

GI Henderson, BG Devi, A Perez… - Alcoholism: Clinical …, 1995 - Wiley Online Library
Prior studies in our laboratory have shown that exposure of cultured fetal rat hepatocytes to
ethanol (E) blocks epidermal growth factor‐dependent replication and that this is paralleled …

Altered adult hippocampal neuronal maturation in a rat model of fetal alcohol syndrome

J Gil-Mohapel, F Boehme, A Patten, A Cox, L Kainer… - Brain research, 2011 - Elsevier
Exposure to ethanol during pregnancy can be devastating to the developing nervous
system, leading to significant central nervous system dysfunction. The hippocampus, one of …

Screening, diagnosing and prevention of fetal alcohol syndrome: is this syndrome treatable

S Ismail, S Buckley, R Budacki, A Jabbar… - Developmental …, 2010 - karger.com
Prenatal alcohol exposure can lead to a wide range of adverse effects on a developing
fetus. As a whole, these teratogenic outcomes are generally known as fetal alcohol spectrum …

Hypothalamic-pituitary-adrenal axis and behavioral dysfunction following early binge-like prenatal alcohol exposure in mice

L Wieczorek, EW Fish, SK O'Leary-Moore, SE Parnell… - Alcohol, 2015 - Elsevier
The range of defects that fall within fetal alcohol spectrum disorder (FASD) includes
persistent behavioral problems, with anxiety and depression being two of the more …

The impact of paternal alcohol consumption on offspring brain and behavioral development

KE Conner, RT Bottom… - Alcoholism: Clinical and …, 2020 - Wiley Online Library
Background Fetal alcohol spectrum disorders (FASD) describe the wide array of long‐
lasting developmental abnormalities in offspring due to prenatal alcohol (ethanol [EtOH]) …

Fetal alcohol spectrum disorders: an overview with emphasis on changes in brain and behavior

EP Riley, CL McGee - Experimental biology and medicine, 2005 - journals.sagepub.com
Fetal alcohol spectrum disorders constitute a major public health problem. This article
presents an overview of important issues that surround these disorders and emphasizes the …

[PDF][PDF] Ethanol, oxidative stress, reactive aldehydes, and the fetus

GI Henderson, JJ Chen, S Schenker - Front Biosci, 1999 - article.imrpress.com
The fetotoxic effects of maternal ethanol (E) consumption have been documented for over
two decades, yet the mechanisms underlying this devastating phenomenon remain …

[HTML][HTML] Focus on: structural and functional brain abnormalities in fetal alcohol spectrum disorders

SC Nuñez, F Roussotte, ER Sowell - Alcohol Research & Health, 2011 - ncbi.nlm.nih.gov
Children exposed to alcohol prenatally can experience significant deficits in cognitive and
psychosocial functioning as well as alterations in brain structure and function related to …

Amelioration of ethanol‐induced neurotoxicity in the neonatal rat central nervous system by antioxidant therapy

MB Heaton, JJ Mitchell, M Paiva - Alcoholism: Clinical and …, 2000 - Wiley Online Library
Background: The cerebellum of the neonatal rat is highly susceptible to ethanol, with
profound loss of Purkinje cells resulting from even brief exposure during the first postnatal …

Fetal alcohol spectrum disorders: a practical clinical approach to diagnosis

MA Manning, HE Hoyme - Neuroscience & Biobehavioral Reviews, 2007 - Elsevier
In utero exposure to alcohol can have numerous adverse effects on a developing fetus.
These effects represent a spectrum of structural anomalies and neurocognitive and …