Single-dose replicating RNA vaccine induces neutralizing antibodies against SARS-CoV-2 in nonhuman primates

JH Erasmus, AP Khandhar, AC Walls, EA Hemann… - bioRxiv, 2020 - biorxiv.org
The ongoing COVID-19 pandemic, caused by infection with SARS-CoV-2, is having a
dramatic and deleterious impact on health services and the global economy. Grim public …

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

JH Erasmus, AP Khandhar, MA O'Connor… - Science translational …, 2020 - science.org
The coronavirus disease 2019 (COVID-19) pandemic, caused by infection with the severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is having a deleterious impact on …

A replicon RNA vaccine can induce durable protective immunity from SARS-CoV-2 in nonhuman primates after neutralizing antibodies have waned

MA O'Connor, DW Hawman, K Meade-White… - Plos …, 2023 - journals.plos.org
The global SARS-CoV-2 pandemic prompted rapid development of COVID-19 vaccines.
Although several vaccines have received emergency approval through various public health …

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine induces equivalent preclinical antibody titers and viral neutralization to recovered COVID-19 patients

PF McKay, K Hu, AK Blakney, K Samnuan, CR Bouton… - BioRXiv, 2020 - biorxiv.org
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset
motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying …

A thermostable mRNA vaccine against COVID-19

NN Zhang, XF Li, YQ Deng, H Zhao, YJ Huang, G Yang… - Cell, 2020 - cell.com
There is an urgent need for vaccines against coronavirus disease 2019 (COVID-19)
because of the ongoing SARS-CoV-2 pandemic. Among all approaches, a messenger RNA …

mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S Rauch, K Gooch, Y Hall, FJ Salguero, MJ Dennis… - Biorxiv, 2020 - biorxiv.org
The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic
necessitates the fast development of vaccines to meet a worldwide need. mRNA-based …

Self-amplifying RNA SARS-CoV-2 lipid nanoparticle vaccine candidate induces high neutralizing antibody titers in mice

PF McKay, K Hu, AK Blakney, K Samnuan… - Nature …, 2020 - nature.com
The spread of the SARS-CoV-2 into a global pandemic within a few months of onset
motivates the development of a rapidly scalable vaccine. Here, we present a self-amplifying …

SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

DW Hawman, K Meade-White, J Archer, SS Leventhal… - Elife, 2022 - elifesciences.org
Despite mass public health efforts, the SARS-CoV2 pandemic continues as of late 2021 with
resurgent case numbers in many parts of the world. The emergence of SARS-CoV2 variants …

mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents

S Rauch, N Roth, K Schwendt, M Fotin-Mleczek… - npj Vaccines, 2021 - nature.com
Abstract mRNA technologies have recently proven clinical efficacy against coronavirus
disease 2019 and are among the most promising technologies to address the current …

A self-amplifying mRNA SARS-CoV-2 vaccine candidate induces safe and robust protective immunity in preclinical models

G Maruggi, CP Mallett, JW Westerbeck, T Chen… - Molecular Therapy, 2022 - cell.com
RNA vaccines have demonstrated efficacy against SARS-CoV-2 in humans, and the
technology is being leveraged for rapid emergency response. In this report, we assessed …