The controversy of combination vs monotherapy in the treatment of hospitalized community-acquired pneumonia

K Weiss, GS Tillotson - Chest, 2005 - Elsevier
Background The majority of community-acquired pneumonia (CAP) patients (about 80%)
will be treated as outpatients, because therapy with a single agent will work. For the …

Monotherapy versus dual therapy for community-acquired pneumonia in hospitalized patients

FJ Martinez - Clinical infectious diseases, 2004 - academic.oup.com
Several medical-specialty professional societies have suggested that combination therapy
with a β-lactam plus a macrolide or doxycycline or monotherapy with a “respiratory …

How good is the evidence for the recommended empirical antimicrobial treatment of patients hospitalized because of community-acquired pneumonia? A systematic …

JJ Oosterheert, MJM Bonten, E Hak… - Journal of …, 2003 - academic.oup.com
Background: For years, monotherapy with a β-lactam antibiotic (penicillin, amoxicillin or
second-generation cephalosporin) was recommended as empirical therapy for patients with …

The dilemma of monotherapy or combination therapy in community‐acquired pneumonia

KZ Vardakas, KK Trigkidis… - European journal of …, 2017 - Wiley Online Library
Scope To study the factors associated with mortality in hospitalized patients with community‐
acquired pneumonia treated with monotherapy or combination therapy. Methods PubMed …

Respiratory fluoroquinolone monotherapy versus β-lactam plus macrolide combination therapy for hospitalized adults with community-acquired pneumonia: A …

SH Choi, A Cesar, TAC Snow, N Saleem… - International Journal of …, 2023 - Elsevier
Introduction Guidelines recommend respiratory fluoroquinolone monotherapy or β-lactam
plus macrolide combination therapy as first-line options for hospitalized adults with mild to …

Fluoroquinolones or macrolides alone versus combined with β-lactams for adults with community-acquired pneumonia: systematic review and meta-analysis

A Raz-Pasteur, D Shasha, M Paul - International journal of antimicrobial …, 2015 - Elsevier
Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality. This
review compared two of the main treatment alternatives: quinolone or macrolide …

Comparison of β-lactam and macrolide combination therapy versus fluoroquinolone monotherapy in hospitalized Veterans Affairs patients with community-acquired …

TP Lodise, A Kwa, L Cosler, R Gupta… - Antimicrobial agents …, 2007 - Am Soc Microbiol
Data comparing the treatment outcomes of the two most frequently recommended empirical
antibiotic regimens for community-acquired pneumonia (CAP)—combination therapy with an …

Combination antibiotic therapy for community-acquired pneumonia

J Caballero, J Rello - Annals of intensive care, 2011 - Springer
Community-acquired pneumonia (CAP) is a common and potentially serious illness that is
associated with morbidity and mortality. Although medical care has improved during the past …

Effect of macrolides as part of initial empiric therapy on medical outcomes for hospitalized patients with community-acquired pneumonia

DS Burgess, JS Lewis II - Clinical therapeutics, 2000 - Elsevier
OBJECTIVE: The goal of this study was to compare the outcomes of hospitalized patients
receiving a nonpseudomonal third-generation cephalosporin with or without a macrolide for …

[PDF][PDF] Antibiotic treatment of moderate-severe community-acquired pneumonia: design and rationale of a multicentre cluster-randomised cross-over trial

CH van Werkhoven, DF Postma, JJ Oosterheert… - Neth J Med, 2014 - njmonline.nl
Background: For the empirical treatment of communityacquired pneumonia requiring
admission to a non-ICU ward, the Dutch guidelines recommend either beta-lactam …