[HTML][HTML] A single-cell atlas of the tumor and immune ecosystem of human breast cancer

J Wagner, MA Rapsomaniki, S Chevrier, T Anzeneder… - Cell, 2019 - cell.com
Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form
ecosystems that determine disease progression and response to therapy. To characterize …

Single-cell profiling to explore immunological heterogeneity of tumor microenvironment in breast cancer

X Yuan, J Wang, Y Huang, D Shangguan… - Frontiers in …, 2021 - frontiersin.org
Immune infiltrates in the tumor microenvironment (TME) of breast cancer (BRCA) have been
shown to play a critical role in tumorigenesis, progression, invasion, and therapy resistance …

Single-cell morphological and topological atlas reveals the ecosystem diversity of human breast cancer

S Zhao, DP Chen, T Fu, JC Yang, D Ma, XZ Zhu… - Nature …, 2023 - nature.com
Digital pathology allows computerized analysis of tumor ecosystem using whole slide
images (WSIs). Here, we present single-cell morphological and topological profiling (sc …

A single-cell and spatially resolved atlas of human breast cancers

SZ Wu, G Al-Eryani, DL Roden, S Junankar, K Harvey… - Nature …, 2021 - nature.com
Breast cancers are complex cellular ecosystems where heterotypic interactions play central
roles in disease progression and response to therapy. However, our knowledge of their …

Single-cell map of diverse immune phenotypes in the breast tumor microenvironment

E Azizi, AJ Carr, G Plitas, AE Cornish, C Konopacki… - Cell, 2018 - cell.com
Knowledge of immune cell phenotypes in the tumor microenvironment is essential for
understanding mechanisms of cancer progression and immunotherapy response. We …

Immune landscape of breast cancers

D Nagarajan, SEB McArdle - Biomedicines, 2018 - mdpi.com
Breast cancer is a very heterogeneous disease, both at a molecular and a histological level.
Five intrinsic subtypes were initially identified—Luminal-A, Luminal-B, HER2+, Triple …

Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer

S Parida, S Siddharth, Y Xia, D Sharma - NPJ Breast Cancer, 2023 - nature.com
Racial disparities are most accentuated among Black women as their lifetime risk of breast
cancer incidence is lower than white and Asian women but their breast cancer related …

Mapping breast cancer microenvironment through single-cell omics

Z Tan, C Kan, M Sun, F Yang, M Wong… - Frontiers in …, 2022 - frontiersin.org
Breast cancer development and progression rely not only on the proliferation of neoplastic
cells but also on the significant heterogeneity in the surrounding tumor microenvironment. Its …

A single‐cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

B Pal, Y Chen, F Vaillant, BD Capaldo, R Joyce… - The EMBO …, 2021 - embopress.org
To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …

A comprehensive analysis of breast cancer microbiota and host gene expression

KJ Thompson, JN Ingle, X Tang, N Chia, PR Jeraldo… - PloS one, 2017 - journals.plos.org
The inflammatory tumoral-immune response alters the physiology of the tumor
microenvironment, which may attenuate genomic instability. In addition to inducing …