Among an impressive variety of identified serotonin receptors, 5-HT 1A attracts particular
attention due to its central role in the regulation of 5-HT-ergic neurotransmission and the …

Numerous investigations have studied in vivo regulation of central 5-HT2A receptors. The
majority of pharmacological studies point to non-classical regulation of this site …

Activation of the 5-HT 4 receptor mediates widespread effects in central and peripheral
nervous systems. Recent developments, such as the identification of novel, selective …

The 5-HT1 receptor family comprises five different pharmacologic subtypes, designated 5-
HT1A, 5-HT1B, 5-HT1C, 5-HT1D, and 5-HT1E, whose common property is to bind 5-HT with …

To investigate the possible functional relationship between 5-HT 1 and 5-HT 2 receptors, we
studied the effects of a nonselective 5-HT agonist (5-MeO DMT), a 5-HT 1A-selective (8-OH …

The 5-ht5A receptor is enigmatic among 5-HT receptors since, although the human receptor
was cloned in 1994, until recently, very little has been learnt about the function of the …

We have isolated from a human genomic library the human 5-hydroxytryptamine 5-HT5A
and 5-HT5B genes. The human 5-HT5A gene encodes a protein with similar characteristics …

The almost incredible complexity of the 5-HT receptor family translates into the diversity of
the brain distribution of these receptors, as briefly illustrated in this chapter. However, the …

The hypothesis that antianxiety or antidepressant agents (eg, 5-HT1A agonists, 5-HT uptake
blockers) exert their clinical action via enhancement of serotonergic neurotransmission due …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …