Nirmatrelvir use and severe Covid-19 outcomes during the Omicron surge

R Arbel, Y Wolff Sagy, M Hoshen, E Battat… - … England Journal of …, 2022 - Mass Medical Soc
Background The oral protease inhibitor nirmatrelvir has shown substantial efficacy in high-
risk, unvaccinated patients infected with the B. 1.617. 2 (delta) variant of severe acute …

Nirmatrelvir and the risk of post-acute sequelae of COVID-19

Y Xie, T Choi, Z Al-Aly - MedRxiv, 2022 - medrxiv.org
Long Covid–the disease encompassing the post-acute sequelae of SARS-CoV-2 (PASC)—
affects millions of people around the world. Prevention of PASC is an urgent public health …

Nirmatrelvir combined with ritonavir for preventing and treating COVID‐19

S Reis, MI Metzendorf, R Kuehn… - Cochrane Database …, 2023 - cochranelibrary.com
Background Oral nirmatrelvir/ritonavir (Paxlovid) aims to avoid severe COVID‐19 in
asymptomatic people or those with mild symptoms, thereby decreasing hospitalization and …

Pharmacokinetics of oral nirmatrelvir/ritonavir, a protease inhibitor for treatment of COVID‐19, in subjects with renal impairment

SS Toussi, JM Neutel, J Navarro… - Clinical …, 2022 - Wiley Online Library
Nirmatrelvir coadministered with ritonavir is highly efficacious in reducing the risk of
coronavirus disease 2019 (COVID‐19) adverse outcomes among patients at increased risk …

Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir

X Chen, X Huang, Q Ma, P Kuzmič, B Zhou… - Nature …, 2024 - nature.com
Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still
needed, particularly for individuals in whom vaccines are less effective, such as the …

New perspectives on antimicrobial agents: molnupiravir and nirmatrelvir/ritonavir for treatment of COVID-19

RL Atmar, N Finch - Antimicrobial agents and chemotherapy, 2022 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has emerged to cause
pandemic respiratory disease in the past 2 years, leading to significant worldwide morbidity …

Association of nirmatrelvir for acute SARS‐CoV‐2 infection with subsequent Long COVID symptoms in an observational cohort study

MS Durstenfeld, MJ Peluso, F Lin… - Journal of Medical …, 2024 - Wiley Online Library
Oral nirmatrelvir/ritonavir is approved as treatment for acute COVID‐19, but the effect of
treatment during acute infection on risk of Long COVID is unknown. We hypothesized that …

Real-world use of nirmatrelvir–ritonavir in outpatients with COVID-19 during the era of omicron variants including BA. 4 and BA. 5 in Colorado, USA: a retrospective …

NR Aggarwal, KC Molina, LE Beaty… - The Lancet Infectious …, 2023 - thelancet.com
Background Nirmatrelvir is a protease inhibitor with in-vitro activity against SARS-CoV-2,
and ritonavir-boosted nirmatrelvir can reduce the risk of progression to severe COVID-19 …

Nirmatrelvir/ritonavir and risk of long COVID symptoms: a retrospective cohort study

S Congdon, Z Narrowe, N Yone, J Gunn, Y Deng… - Scientific reports, 2023 - nature.com
We conducted a retrospective cohort study to assess whether treatment with
nirmatrelvir/ritonavir was associated with a reduced risk of long COVID. We enrolled 500 …

Efficacy of nirmatrelvir and ritonavir for post‐acute COVID‐19 sequelae beyond 3 months of SARS‐CoV‐2 infection

MH Chuang, JY Wu, TH Liu, WH Hsu… - Journal of Medical …, 2023 - Wiley Online Library
The effect of nirmatrelvir plus ritonavir (NMV‐r) on post‐acute COVID‐19 sequelae beyond 3
months of SARS‐CoV‐2 infection remains unknown. This retrospective cohort study utilized …