Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections

HL Itell, A Kaur, JD Deere, PA Barry… - Current opinion in virology, 2017 - Elsevier
Highlights•Nonhuman primate (NHP) CMVs are most closely related to human CMV
(HCMV).•Rhesus CMV (RhCMV) bears numerous genomic and functional similarities to …

Rhesus cytomegalovirus: A nonhuman primate model for the study of human cytomegalovirus

Y Yue, PA Barry - Advances in virus research, 2008 - Elsevier
Human cytomegalovirus (HCMV), a member of an ancient family of viruses (Herpesviridae),
has acquired the capacity to maintain a lifelong persistent infection within an …

Pre-existing immunity to cytomegalovirus in macaques influences human CMV vaccine responses in preclinical models

H Webster, S Valencia, A Kumar, C Chan, M Dennis… - Vaccine, 2021 - Elsevier
Abstract Development of a human cytomegalovirus (HCMV) vaccine is a Tier 1 priority by the
National Institutes of Medicine, as HCMV is the most common congenital infection globally …

Nonhuman primate models of intrauterine cytomegalovirus infection

PA Barry, KM Lockridge, S Salamat, SP Tinling… - ILAR …, 2006 - academic.oup.com
Congenital human cytomegalovirus (HCMV) infection has long been recognized as a threat
to the developing fetus, even though studies have shown that only a subset of congenital …

[HTML][HTML] Examining the species-specificity of rhesus macaque cytomegalovirus (RhCMV) in cynomolgus macaques

AK Marsh, AP Ambagala, CT Perciani, JNH Russell… - PLoS …, 2015 - journals.plos.org
Cytomegalovirus (CMV) is a highly species-specific virus that has co-evolved with its host
over millions of years and thus restricting cross-species infection. To examine the extent to …

Rodent models of congenital cytomegalovirus infection

B Lisnić, J Tomac, D Cekinović, S Jonjić… - … : Methods and protocols, 2021 - Springer
Human cytomegalovirus (HCMV) is a leading viral cause of congenital infections in the
central nervous system (CNS) and may result in severe long-term sequelae. High rates of …

[HTML][HTML] In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome

H Taher, E Mahyari, C Kreklywich, LS Uebelhoer… - PLoS …, 2020 - journals.plos.org
Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict
species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal …

[HTML][HTML] Using the nonhuman primate model of HCMV to guide vaccine development

JD Deere, PA Barry - Viruses, 2014 - mdpi.com
The natural history of human cytomegalovirus (HCMV) is inextricably associated with
mucosal surfaces. The vast preponderance of primary infections occur following mucosal …

[PDF][PDF] Non-human-primate models of cytomegalovirus infection, prevention, and therapy

K Früh, D Malouli, KL Oxford… - … molecular pathogenesis to …, 2013 - researchgate.net
Abstract e last few years have witnessed significant expansion of the Non-Human-Primate
(NHP) models of CMV persistence and pathogenesis. Progress in the utilization of the NHP …

[HTML][HTML] Cross-species rhesus cytomegalovirus infection of cynomolgus macaques

BJ Burwitz, D Malouli, BN Bimber, JS Reed… - PLoS …, 2016 - journals.plos.org
Cytomegaloviruses (CMV) are highly species-specific due to millennia of co-evolution and
adaptation to their host, with no successful experimental cross-species infection in primates …