[HTML][HTML] A multi-network approach identifies protein-specific co-expression in asymptomatic and symptomatic Alzheimer's disease
Here, we report proteomic analyses of 129 human cortical tissues to define changes
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
associated with the asymptomatic and symptomatic stages of Alzheimer's disease (AD) …
Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
Integrated proteomics and network analysis identifies protein hubs and network alterations in Alzheimer's disease
Q Zhang, C Ma, M Gearing, PG Wang, LS Chin… - Acta neuropathologica …, 2018 - Springer
Although the genetic causes for several rare, familial forms of Alzheimer's disease (AD) have
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …
been identified, the etiology of the sporadic form of AD remains unclear. Here, we report a …
A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting millions of
elderly individuals worldwide. Advances in the genetics of AD have led to new levels of …
elderly individuals worldwide. Advances in the genetics of AD have led to new levels of …
Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease
Background The complicated cellular and biochemical changes that occur in brain during
Alzheimer's disease are poorly understood. In a previous study we used an unbiased label …
Alzheimer's disease are poorly understood. In a previous study we used an unbiased label …
Identification of conserved proteomic networks in neurodegenerative dementia
Data-driven analyses are increasingly valued in modern medicine. We integrate quantitative
proteomics and transcriptomics from over 1,000 post-mortem brains from six cohorts …
proteomics and transcriptomics from over 1,000 post-mortem brains from six cohorts …
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
Multicellular communities are perturbed in the aging human brain and Alzheimer's disease
The role of different cell types and their interactions in Alzheimer's disease (AD) is a complex
and open question. Here, we pursued this question by assembling a high-resolution cellular …
and open question. Here, we pursued this question by assembling a high-resolution cellular …
Genes and pathways underlying regional and cell type changes in Alzheimer's disease
Abstract Background Transcriptional studies suggest Alzheimer's disease (AD) involves
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …
dysfunction of many cellular pathways, including synaptic transmission, cytoskeletal …