The worldwide pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is unprecedented and the impact on public health and the global economy …

The continued threat of SARS-CoV-2 to global health necessitates development of improved
research tools and vaccines. We present an improved SARS-CoV-2 spike …

SARS-CoV-2 is the causative agent of the COVID-19 pandemic, with 10 million infections
and more than 500,000 fatalities by June 2020. To initiate infection, the SARS-CoV-2 spike …

Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-
CoV-2 infection is crucial for understanding immune protection and identifying targets for …

Designing prefusion-stabilized SARS-CoV-2 spike is critical for the effectiveness of COVID-
19 vaccines. All COVID-19 vaccines in the US encode spike with K986P/V987P mutations to …

In this study, we used an integrative computational approach to examine molecular
mechanisms and determine functional signatures underlying the role of functional residues …

The development of computational strategies for the quantitative characterization of the
functional mechanisms of SARS-CoV-2 spike proteins is of paramount importance in efforts …

The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need
for highly effective vaccine candidates that are thermostable and amenable to large-scale …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus
disease 2019 (COVID-19), is a novel beta coronavirus. SARS-CoV-2 uses spike …

Increasing the expression level of the SARS-CoV-2 spike (S) protein has been critical for
COVID-19 vaccine development. While previous efforts largely focused on engineering the …