mRNA vaccine CVnCoV protects non-human primates from SARS-CoV-2 challenge infection

S Rauch, K Gooch, Y Hall, FJ Salguero, MJ Dennis… - Biorxiv, 2020 - biorxiv.org
The ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic
necessitates the fast development of vaccines to meet a worldwide need. mRNA-based …

[HTML][HTML] mRNA-based SARS-CoV-2 vaccine candidate CVnCoV induces high levels of virus-neutralising antibodies and mediates protection in rodents

S Rauch, N Roth, K Schwendt, M Fotin-Mleczek… - npj Vaccines, 2021 - nature.com
Abstract mRNA technologies have recently proven clinical efficacy against coronavirus
disease 2019 and are among the most promising technologies to address the current …

Phase 1 assessment of the safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 in human volunteers

P Kremsner, P Mann, J Bosch, R Fendel, JJ Gabor… - MedRxiv, 2020 - medrxiv.org
There is an urgent need for vaccines to counter the COVID-19 pandemic due to infections
with severe acute respiratory syndrome coronavirus (SARS-CoV-2). Evidence from …

[HTML][HTML] Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

MS Gebre, S Rauch, N Roth, J Yu, A Chandrashekar… - Nature, 2022 - nature.com
Abstract The CVnCoV (CureVac) mRNA vaccine for severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) was recently evaluated in a phase 2b/3 efficacy trial in …

[HTML][HTML] Long-term stability and protection efficacy of the RBD-targeting COVID-19 mRNA vaccine in nonhuman primates

H Zhao, TC Wang, XF Li, NN Zhang, L Li… - Signal transduction and …, 2021 - nature.com
Messenger RNA (mRNA) vaccine technology has shown its power in preventing the
ongoing COVID-19 pandemic. Two mRNA vaccines targeting the full-length S protein of …

[HTML][HTML] SARS-CoV-2 mRNA-vaccine candidate; COReNAPCIN®, induces robust humoral and cellular immunity in mice and non-human primates

R Alimohammadi, M Porgoo, M Eftekhary, SH Kiaie… - NPJ vaccines, 2022 - nature.com
At the forefront of biopharmaceutical industry, the messenger RNA (mRNA) technology
offers a flexible and scalable platform to address the urgent need for world-wide …

[PDF][PDF] CV2CoV, an enhanced mRNA-based SARS-CoV-2 vaccine candidate, supports higher protein expression and improved immunogenicity in rats

N Roth, J Schön, D Hoffmann, M Thran, A Thess… - …, 2021 - sostelemedicina.ucv.ve
More than a year after emergence of the SARS-CoV-2 pandemic, multiple first-generation
vaccines are approved and available for vaccination. Still, many challenges remain. The …

[HTML][HTML] Multiplexed LNP-mRNA vaccination against pathogenic coronavirus species

L Peng, Z Fang, PA Renauer, A McNamara, JJ Park… - Cell Reports, 2022 - cell.com
Although COVID-19 vaccines have been developed, multiple pathogenic coronavirus
species exist, urging on development of multispecies coronavirus vaccines. Here we …

Monovalent SARS-COV-2 mRNA vaccine using optimal UTRs and LNPs is highly immunogenic and broadly protective against Omicron variants

Z Ye, SR Bonam, LGA McKay… - Proceedings of the …, 2023 - National Acad Sciences
The emergence of highly transmissible severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variants of concern (VOCs) that are resistant to the current COVID-19 …

[HTML][HTML] A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice

D Laczkó, MJ Hogan, SA Toulmin, P Hicks, K Lederer… - Immunity, 2020 - cell.com
SARS-CoV-2 infection has emerged as a serious global pandemic. Because of the high
transmissibility of the virus and the high rate of morbidity and mortality associated with …