Type I interferons in COVID-19 pathogenesis

E Palermo, D Di Carlo, M Sgarbanti, J Hiscott - Biology, 2021 - mdpi.com
Simple Summary The innate antiviral immune response is essential to limit virus replication
at early stages of infection, thus preventing viral spread and pathogenesis. Nevertheless …

Antagonism of type I interferon by severe acute respiratory syndrome coronavirus 2

H Xia, PY Shi - Journal of Interferon & Cytokine Research, 2020 - liebertpub.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), warranting urgent study of the molecular …

Type I and III interferon responses in SARS-CoV-2 infection

YM Kim, EC Shin - Experimental & molecular medicine, 2021 - nature.com
Abstract Coronavirus disease 2019 (COVID-19), the current pandemic disease, is caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Type I and III …

Type I and type III interferons: From basic biology and genetics to clinical development for COVID-19 and beyond

E Andreakos, CHG Effort - Seminars in Immunology, 2024 - Elsevier
Type I and type III interferons (IFNs) constitute a key antiviral defense systems of the body,
inducing viral resistance to cells and mediating diverse innate and adaptive immune …

Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection

C Chiale, TT Greene, EI Zuniga - Immunological Reviews, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …

[HTML][HTML] Type I and type III interferons–induction, signaling, evasion, and application to combat COVID-19

A Park, A Iwasaki - Cell host & microbe, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a global pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Without approved antiviral therapeutics …

Type I interferons and SARS-CoV-2: from cells to organisms

P Bastard, Q Zhang, SY Zhang, E Jouanguy… - Current Opinion in …, 2022 - Elsevier
Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …

Interplay between SARS-CoV-2 and the type I interferon response

M Sa Ribero, N Jouvenet, M Dreux, S Nisole - PLoS pathogens, 2020 - journals.plos.org
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. An unbalanced immune response, characterized by a weak …

Characterization of SARS-CoV-2 evasion: interferon pathway and therapeutic options

M Znaidia, C Demeret, S van der Werf, AV Komarova - Viruses, 2022 - mdpi.com
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current COVID-19 pandemic. SARS-CoV-2 is characterized by an important capacity to …

Type I and III IFN-mediated antiviral actions counteracted by SARS-CoV-2 proteins and host inherited factors

J Quarleri, MV Delpino - Cytokine & Growth Factor Reviews, 2021 - Elsevier
SARS-CoV-2 is a recently identified coronavirus accountable for the current pandemic
disease known as COVID-19. Different patterns of disease progression infer a diverse host …