There is a widening recognition that cancer cells are products of complex developmental
processes. Carcinogenesis and metastasis formation are increasingly described as systems …

Cancer is increasingly described as a systems-level, network phenomenon. Genetic
methods, such as next generation sequencing and RNA interference uncovered the …

Cancer is increasingly perceived as a systems-level, network phenomenon. The major trend
of malignant transformation can be described as a two-phase process, where an initial …

The era of targeted cancer therapies has arrived. However, due to the complexity of
biological systems, the current progress is far from enough. From biological network …

Cancer is a complex and heterogeneous disease, demonstrating variations with respect to
tumor types and between individual tumors. This heterogeneity has complicated the search …

Cancer genetics has led to major discoveries, including protooncogene and tumor‐
suppressor concepts, and cancer genomics generated concepts like driver and passenger …

Current and emerging biomedical science efforts are driven by determining how to improve
clinical outcomes for patients, but the roadmap to achieve this goal has been controversial …

Facing metastasis is the most pressing challenge of cancer research. In this review, we
discuss recent advances in understanding phenotypic plasticity of cancer cells, highlighting …

A long-standing paradigm in drug discovery has been the concept of designing maximally
selective drugs to act on individual targets considered to underlie a disease of interest …

Background The molecular mechanisms underlying innate tumor drug resistance, a major
obstacle to successful cancer therapy, remain poorly understood. In colorectal cancer …