Background The histone variant H3. 3 plays key roles in regulating chromatin states and
transcription. However, the role of endogenous H3. 3 in mammalian cells and during …

Histone variant H3. 3 plays novel roles in development as compared to canonical H3
proteins and is the most commonly mutated histone protein of any kind in human disease …

Histone H3. 3 is a highly conserved histone H3 replacement variant in metazoans and has
been implicated in many important biological processes, including cell differentiation and …

The histone variant H3. 3 is involved in diverse biological processes, including
development, transcriptional memory and transcriptional reprogramming, as well as …

Histones package DNA and regulate epigenetic states. For the latter, probably the most
important histone is H3. Mammals have three near-identical H3 isoforms: canonical H3. 1 …

Nucleosomal incorporation of specialized histone variants is an important mechanism to
generate different functional chromatin states. Here, we describe the identification and …

The incorporation of histone variants into chromatin plays an important role for the
establishment of particular chromatin states. Six human histone H3 variants are known to …

Histone H1 is a structural component of chromatin that may have a role in the regulation of
chromatin dynamics. Unlike core histones, the linker histone H1 family is evolutionarily …

H1 linker histones are key chromatin architectural proteins facilitating the formation of higher
order chromatin structures. The H1 family constitutes the most heterogeneous group of …

The lysine-rich H1 histone family in mammals includes eleven different subtypes, and thus it
is the most divergent class of histone proteins. The central globular H1 domain …