Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a
dynamic inflammatory microenvironment consisting of a complex network formed by the …

Foxp3+ CD4+ regulatory T cells (Tregs) play important roles in controlling both homeostatic
processes and immune responses at the tissue and organismal levels. For example, Tregs …

Long recognized to be potent suppressors of immune responses, Foxp3+ CD4+ regulatory T
(Treg) cells are being rediscovered as regulators of nonimmunological processes. We …

The identification of stem cells and growth factors as well as the development of biomaterials
hold great promise for regenerative medicine applications. However, the therapeutic efficacy …

Skeletal muscle regeneration is a highly orchestrated process that depends on multiple
immune-system cell types, notably macrophages (MFs) and Foxp3+ CD4+ regulatory T …

Skeletal muscle regeneration results from the activation and differentiation of myogenic stem
cells, called satellite cells, located beneath the basal lamina of the muscle fibers …

Muscle injury induces a classical inflammatory response in which cells of the innate immune
system rapidly invade the tissue. Macrophages are prominently involved in this response …

Accumulating evidence has demonstrated that immune cells play an important role in the
regulation of tissue repair and regeneration. After injury, danger signals released by the …

We examined the hypothesis that regulatory T cells (Tregs) modulate muscle injury and
inflammation in the mdx mouse model of Duchenne muscular dystrophy (DMD). Although …

Maintenance of tissue integrity in skeletal muscle requires the immunomodulatory and
regenerative functions of muscle-resident regulatory T cells (Tregs). Chronic skeletal muscle …