Systems approaches have long been used in pharmacology to understand drug action at
the organ and organismal levels. The application of computational and experimental …

Abstract Systems biology uses experimental and computational approaches to characterize
large sample populations systematically, process large datasets, examine and analyze …

Abstract Systems pharmacology involves the application of systems biology approaches,
combining large‐scale experimental studies with computational analyses, to the study of …

To achieve sensitive and specific mechanism-based prediction of drug toxicity, the tools of
systems pharmacology will be integrated using structured ontological approaches, analytics …

The complexity of human biology makes it challenging to develop safe and effective new
medicines. Systems biology omics-based efforts have led to an explosion of high-throughput …

Genome medicine uses genomic information in the diagnosis of disease and in prescribing
treatment. This transdisciplinary field brings together knowledge on the relationships …

Abstract Systems pharmacology is an emerging area of pharmacology which utilizes
network analysis of drug action as one of its approaches. By considering drug actions and …

There is notable interindividual heterogeneity in drug response, affecting both drug efficacy
and toxicity, resulting in patient harm and the inefficient utilization of limited healthcare …

High‐throughput experimental techniques for generating genomes, transcriptomes,
proteomes, metabolomes, and interactomes have provided unprecedented opportunities to …

Systems biology is in an exponential development stage in recent years and has been
widely utilized in biomedicine to better understand the molecular basis of human disease …