COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
The outbreak of the novel SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2)
responsible for coronavirus disease 2019 (COVID-19) has developed into an …

[HTML][HTML] Cytokine “storm”, cytokine “breeze”, or both in COVID-19?

G Lippi, M Plebani - Clinical Chemistry and Laboratory Medicine …, 2021 - degruyter.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic outbreak, which has
seemingly emerged in Wuhan (China) at the end of 2019, has now spread all around the …

The pro-inflammatory cytokines in COVID-19 pathogenesis: What goes wrong?

D Darif, I Hammi, A Kihel, IEI Saik, F Guessous… - Microbial …, 2021 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) infection, has emerged in China in December 2019 …

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

DE Leisman, L Ronner, R Pinotti, MD Taylor… - The Lancet …, 2020 - thelancet.com
The description of a so-called cytokine storm in patients with COVID-19 has prompted
consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However …

[HTML][HTML] Immune system response during viral Infections: Immunomodulators, cytokine storm (CS) and Immunotherapeutics in COVID-19

FH Pottoo, T Abu-Izneid, AM Ibrahim, MN Javed… - Saudi pharmaceutical …, 2021 - Elsevier
Coronaviruses are non-segmented and single stranded positive-sense RNA (+ ssRNA)
viruses. To date, 06 human coronaviruses (HCoVs) are reported; α-CoVs (HCoVs-NL63 and …

[HTML][HTML] Cytokine storm in COVID-19: from viral infection to immune responses, diagnosis and therapy

Y Jiang, L Rubin, T Peng, L Liu, X Xing… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive
production of proinflammatory cytokines, also known as cytokine storm, is a severe clinical …

Immune signature of covid-19: In-depth reasons and consequences of the cytokine storm

P Niedźwiedzka-Rystwej, A Majchrzak… - International Journal of …, 2022 - mdpi.com
In the beginning of the third year of the fight against COVID-19, the virus remains at least still
one step ahead in the pandemic “war”. The key reasons are evolving lineages and …

Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome

LYC Chen, RL Hoiland, S Stukas… - European …, 2020 - Eur Respiratory Soc
The concept of coronavirus disease 2019 (COVID-19)-related cytokine storm syndrome
(COVID-CSS) emerged early in the severe acute respiratory syndrome coronavirus 2 (SARS …

Potential therapeutic approaches for targeted inhibition of inflammatory cytokines following COVID-19 infection-induced cytokine storm

N Morgulchik, F Athanasopoulou, E Chu… - Interface …, 2021 - royalsocietypublishing.org
Coronavirus disease 2019 (COVID-19) is a deadly respiratory disease caused by severe
acute respiratory syndrome coronavirus 2, which has caused a global pandemic since early …

“Cytokine storm”, not only in COVID-19 patients. Mini-review

N Lukan - Immunology Letters, 2020 - Elsevier
Highlights•Clinical picture generally manifests as “overlap syndrome” and leads to vicious
circle.•Early identification of rising cytokine storm and multilevel course of treatment is …