Abstract Carlson, DJ, Stewart, RD, Semenenko, VA and Sandison, GA Combined Use of
Monte Carlo DNA Damage Simulations and Deterministic Repair Models to Examine …

Several proteins involved in DNA repair and DNA damage signaling have been shown to
produce discrete foci in response to ionizing radiation. These foci are believed to co-localize …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Radiation quality and cellular oxygen concentration have a substantial impact on DNA
damage, reproductive cell death and, ultimately, the potential efficacy of radiation therapy for …

High-linear-energy-transfer (LET) radiation is more lethal than similar doses of low-LET
radiation types, probably a result of the condensed energy deposition pattern of high-LET …

More than half of cancer patients receive radiotherapy as a part of their cancer treatment.
DNA double-strand breaks (DSBs) are considered as the most lethal form of DNA damage …

Low-and high-linear energy transfer (LET) ionising radiation are effective cancer therapies,
but produce structurally different forms of DNA damage. Isolated DNA damage is repaired …

A widely accepted assumption in radiobiology is that ionizing radiation kills cells by inducing
forms of damage in DNA structures that lead to the formation of lethal chromosome …

To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …

The prevailing hypothesis on the mechanism of radiation-induced cell killing identifies the
genetic material deoxyribonucleic acid (DNA) as the most important subcellular target at …