Coronavirus is the trigger, but the immune response is deadly

RQ Cron - The Lancet Rheumatology, 2020 - thelancet.com
As of mid-April, 2020, severe acute respiratory syn drome coronavirus 2 (SARS-CoV-2), the
coronavirus respon sible for COVID-19, has infected more than 4· 4 million people …

COVID-19: consider cytokine storm syndromes and immunosuppression

P Mehta, DF McAuley, M Brown, E Sanchez… - The lancet, 2020 - thelancet.com
As of March 12, 2020, coronavirus disease 2019 (COVID-19) has been con firmed in 125
048 people worldwide, carrying a mortality of approximately 3· 7%, 1 compared with a …

COVID-19 cytokine storm: targeting the appropriate cytokine

RQ Cron - The Lancet Rheumatology, 2021 - thelancet.com
As of January, 2021, nearly 2-million deaths worldwide have been attributed to COVID-19,
which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much …

2019 novel coronavirus pandemic: what do we know?

LN Margallo II, M Diaz, PP Lim - South Dakota Medicine, 2020 - search.ebscohost.com
The pandemic caused by SARS-COV2 Virus/COVID-19, which was initially reported in
China in December 2019, has become a major global health concern. COVID-19 can …

COVID-19 cytokine storm syndrome: a threshold concept

LYC Chen, TTT Quach - The Lancet Microbe, 2021 - thelancet.com
The COVID-19 pandemic has placed the practice of medicine at a threshold overlooking a
new and different era, 1 and has led to the evolving concept of COVID-19 cytokine storm …

Should COVID-19 take advice from rheumatologists?

KF Kernan, SW Canna - The Lancet Rheumatology, 2020 - thelancet.com
Coronavirus disease 2019 (COVID-19) has left an indelible mark on 21st century history, but
in the ancient saga of humans and the viruses we encounter, what makes this chapter so …

[PDF][PDF] Cytokine-targeted therapy in severely ill COVID-19 patients: options and cautions

M Rahmati, MA Moosavi - mortality, 2020 - researchgate.net
Dear Editor, Coronavirus disease 2019 (COVID-19) is an infectious disease caused by
severe acute respiratory syndrome coronavirus 2 (SARS‐CoV-2) with the symptoms …

[HTML][HTML] Covid‐19: time for a paradigm change

FM Buonaguro, PA Ascierto, GD Morse… - Reviews in medical …, 2020 - ncbi.nlm.nih.gov
As of May 11, 2020, coronavirus disease 2019 (Covid-19) has been confirmed in 4 152 670
people worldwide, carrying a mortality of approximately 6.8%, 1 compared with a mortality …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

Could SARS-CoV-2-induced hyperinflammation magnify the severity of coronavirus disease (CoViD-19) leading to acute respiratory distress syndrome?

ASS Girija, EM Shankar, M Larsson - Frontiers in immunology, 2020 - frontiersin.org
The exaggerated immune response induced in the lower respiratory tract against
coronaviruses (CoVs), including CoViD-19 (2019-nCoV), appears to contribute to the …