The roles of polyphenols in cancer chemoprevention

KW Lee, HJ Lee - Biofactors, 2006 - Wiley Online Library
Oxidative stress imposed by reactive oxygen species (ROS) plays a crucial role in the
pathophysiology associated with neoplasia, atherosclerosis, and neurodegenerative …

The effects of polyphenols on oxidative stress and the arachidonic acid cascade. Implications for the prevention/treatment of high prevalence diseases

MT Mitjavila, JJ Moreno - Biochemical pharmacology, 2012 - Elsevier
Redox state unbalance and the activation of the arachidonic acid (AA) cascade, contribute to
the pathogenesis of cardiovascular disease (CVD) and cancer. Inflammatory cells that …

Health benefits of phenolic compounds against cancers

A Basli, N Belkacem, I Amrani - Phenolic compounds-biological …, 2017 - books.google.com
Phenolic compounds are the biggest group of phytochemicals, and many of them have been
found in plant-based foods. Polyphenol-rich diets have been linked to many health benefits …

Oxidative stress and dietary phytochemicals: Role in cancer chemoprevention and treatment

S Chikara, LD Nagaprashantha, J Singhal, D Horne… - Cancer letters, 2018 - Elsevier
Several epidemiological observations have shown an inverse relation between
consumption of plant-based foods, rich in phytochemicals, and incidence of cancer …

Research strategies in the study of the pro‐oxidant nature of polyphenol nutraceuticals

H Babich, AG Schuck, JH Weisburg… - Journal of …, 2011 - Wiley Online Library
Polyphenols of phytochemicals are thought to exhibit chemopreventive effects against
cancer. These plant‐derived antioxidant polyphenols have a dual nature, also acting as pro …

Pro-oxidant activity of polyphenols and its implication on cancer chemoprevention and chemotherapy

AJ León-González, C Auger, VB Schini-Kerth - Biochemical pharmacology, 2015 - Elsevier
Reactive oxygen species (ROS) play a major role in carcinogenesis: pro-oxidant agents like
tobacco smoke, asbestos or N-nitrosamines, are known as mutagenic and carcinogenic, and …

Polyphenols as small molecular inhibitors of signaling cascades in carcinogenesis

NJ Kang, SH Shin, HJ Lee, KW Lee - Pharmacology & therapeutics, 2011 - Elsevier
Multiple lines of evidences suggest that oxidative stress induced by reactive oxygen species
are closely related to multi-stage carcinogenesis. Polyphenols, a group of chemicals with …

Polyphenols as modulator of oxidative stress in cancer disease: new therapeutic strategies

AM Mileo, S Miccadei - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Cancer onset and progression have been linked to oxidative stress by increasing DNA
mutations or inducing DNA damage, genome instability, and cell proliferation and therefore …

Biphasic effects of dietary antioxidants on oxidative stress-mediated carcinogenesis

KW Lee, HJ Lee - Mechanisms of ageing and development, 2006 - Elsevier
There is now strong evidence implicating the generation of reactive oxygen species (ROS)
and the corresponding response to oxidative stress as key factors in the pathogenesis of …

Cancer chemoprevention through dietary antioxidants: progress and promise

N Khan, F Afaq, H Mukhtar - Antioxidants & redox signaling, 2008 - liebertpub.com
It is estimated that nearly one-third of all cancer deaths in the United States could be
prevented through appropriate dietary modification. Various dietary antioxidants have …