[HTML][HTML] Covid‐19: time for a paradigm change

FM Buonaguro, PA Ascierto, GD Morse… - Reviews in medical …, 2020 - ncbi.nlm.nih.gov
As of May 11, 2020, coronavirus disease 2019 (Covid-19) has been confirmed in 4 152 670
people worldwide, carrying a mortality of approximately 6.8%, 1 compared with a mortality …

Review on therapeutic targets for COVID-19: insights from cytokine storm

ML de Mélo Silva Júnior, LMA de Souza… - Postgraduate …, 2021 - academic.oup.com
Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
caused the greatest pandemic of our century. Many of the deaths related to it are due to a …

[HTML][HTML] COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

Cytokine storm and the prospects for immunotherapy with COVID-19.

LH Calabrese - Cleveland Clinic journal of medicine, 2020 - europepmc.org
Knowledge about the pathobiology of SARS-CoV-2 as it interacts with immune defenses is
limited. SARS-CoV-2 is spread by droplets that come into contact with mucous membranes …

[HTML][HTML] The COVID-19 cytokine storm; what we know so far

D Ragab, H Salah Eldin, M Taeimah… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the
WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract …

[PDF][PDF] COVID-19 pandemic: from origins to outcomes. A comprehensive review of viral pathogenesis, clinical manifestations, diagnostic evaluation, and management

R Ochani, A Asad, F Yasmin, S Shaikh, H Khalid… - Infez Med, 2021 - infezmed.it
SUMMARY majority of patients tend to have a mild illness, a minority of patients develop
severe hypoxia requiring hospitalization and mechanical ventilation. Management is mostly …

[HTML][HTML] The cytokine storm in COVID-19: the strongest link to morbidity and mortality in the current epidemic

M Basheer, E Saad, N Assy - COVID, 2022 - mdpi.com
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The clinical
presentations of the SARS-CoV-2 infection are widely variable and treatment strategies for …

[HTML][HTML] Cytokine storm in COVID-19: immunopathogenesis and therapy

C Zanza, T Romenskaya, AC Manetti, F Franceschi… - Medicina, 2022 - mdpi.com
A cytokine storm is a hyperinflammatory state secondary to the excessive production of
cytokines by a deregulated immune system. It manifests clinically as an influenza-like …

[HTML][HTML] Cytokine storm in COVID-19: pathogenesis and overview of anti-inflammatory agents used in treatment

M Soy, G Keser, P Atagündüz, F Tabak… - Clinical …, 2020 - Springer
COVID-19 infection has a heterogenous disease course; it may be asymptomatic or causes
only mild symptoms in the majority of the cases, while immunologic complications such as …

[HTML][HTML] Outbreak of COVID-19: An emerging global pandemic threat

M Peng - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Since the first outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection in Wuhan, Hubei, China in December 2019, it is now recognized as a pandemic by …