Recent insights into the genetics of inflammatory bowel disease

JH Cho, SR Brant - Gastroenterology, 2011 - Elsevier
Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders that comprise
Crohn's disease (CD) and ulcerative colitis (UC). Genome-wide association studies have …

Determinants of IBD heritability: genes, bugs, and more

W Turpin, A Goethel, L Bedrani… - Inflammatory bowel …, 2018 - academic.oup.com
Defining the etiology of inflammatory bowel disease (IBD) continues to elude researchers, in
part due to the possibility that there may be different triggers for a spectrum of disease …

A genome-wide search identifies potential new susceptibility loci for Crohn's disease

Y Ma, JD Ohmen, Z Li, GL Bentley… - Inflammatory bowel …, 1999 - academic.oup.com
Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's
disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal …

Towards a molecular risk map—recent advances on the etiology of inflammatory bowel disease

P Rosenstiel, C Sina, A Franke, S Schreiber - Seminars in immunology, 2009 - Elsevier
Recent advances have enabled a comprehensive understanding of the genetic architecture
of inflammatory bowel disease (IBD) with over 30 identified and replicated disease loci. The …

The genetics of inflammatory bowel disease

J Van Limbergen, RK Russell, ER Nimmo… - Official journal of the …, 2007 - journals.lww.com
Great progress in the understanding of the molecular genetics of inflammatory bowel
disease (IBD) has been made over the last 10 years. Strong epidemiological evidence …

Inflammatory bowel disease: between genetics and microbiota

N Younis, R Zarif, R Mahfouz - Molecular biology reports, 2020 - Springer
Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disease that can
involve any part of the gastrointestinal tract. It includes two main disorders: Crohn's disease …

The genetic background of inflammatory bowel disease: from correlation to causality

WTC Uniken Venema, MD Voskuil… - The Journal of …, 2017 - Wiley Online Library
Recent studies have greatly improved our insight into the genetic background of
inflammatory bowel disease (IBD). New high‐throughput technologies and large‐scale …

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

HH Uhlig - Gut, 2013 - gut.bmj.com
Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has
multifactorial aetiology with complex interactions between genetic and environmental …

Genetics of inflammatory bowel disease: implications for disease pathogenesis and natural history

CW Lees, J Satsangi - Expert review of gastroenterology & …, 2009 - Taylor & Francis
Epidemiological data, detailed molecular studies and recent genome-wide association
studies strongly suggest that ulcerative colitis (UC) and Crohn's disease (CD) are related …

Recent advances in the genetics of inflammatory bowel disease

B Newman, KA Siminovitch - Current opinion in gastroenterology, 2005 - journals.lww.com
The application of genetic information to diagnosis and risk prediction in inflammatory bowel
disease will require comprehensive knowledge of the relevant susceptibility alleles …