Background Inflammatory bowel diseases (IBD) result from an interaction between genetic
and environmental factors. Preliminary findings suggest that susceptibility genes differ …

The relevance of genetic and epigenetic alterations in the pathogenesis of inflammatory
bowel disease (IBD) is still poorly understood. So far, 240 risk gene loci have been …

The inflammatory bowel diseases (IBD) comprise complex genetic disorders, with multiple
contributing genes. Linkage studies have implicated several genomic regions as likely …

Background & Aims The contribution of genetic factors to the pathogenesis of inflammatory
bowel disease (IBD) has been established by twin, targeted-sequencing, and genome-wide …

The idiopathic inflammatory bowel diseases, Crohn's disease (CD) and ulcerative colitis
(UC), are chronic, frequently disabling diseases of the intestines. Segregation analyses, twin …

Crohn's disease and ulcerative colitis constitute two major subgroups of inflammatory bowel
diseases (IBD), a group of complex polygenic diseases characterized by chronic and …

Rare, monogenetic diseases present unique models to dissect gene functions and
biological pathways, concomitantly enhancing our understanding of the etiology of complex …

Recent genome-wide genetic association studies and advances in molecular analysis of
microbial composition have improved dramatically our understanding of the pathogenesis of …

Crohn's disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …

The pathogenesis of inflammatory bowel disease (IBD) is not well-understood; however,
increased and persistent intestinal inflammation, due to inappropriate immune responses …