Conducting pediatric research lacking clinical benefit to the subjects is sometimes essential
to test clinical interventions for children (Institute of Medicine [IOM] 2004; Wendler 2010) …

A comparison might make this point clearer. Often during elections in the United States,
people will leave the voting station choosing to wear a sign that says,“I Voted!” Even though …

Pediatric participation in non-therapeutic research that poses greater than minimal risk has
been the subject of considerable thought-provoking debate in the research ethics literature …

Fisher et al.(2007) offer a clear and concise analysis of United States federal regulations
and recommendations regarding research in children with no prospect of direct benefit …

Within the past four decades, there has been increasing concern about the participation of
children in medical research. The foundational role of informed consent in the ethics and …

No one produces more thoughtful and insightful work on the ethics of pediatric research than
Dave Wendler. I claim, though, that there is a more persuasive justification for pediatric …

Pediatric research without the potential for clinical benefit is vital to improving pediatric
medical care. This research also raises ethical concern and is regarded by courts and …

In recent decades, advances in biomedical research have helped save or lengthen the lives
of children around the world. With improved therapies, child and adolescent mortality rates …

Because most children are unable to provide informed consent, some guidelines exclude
them from participation in clinical research. The German guidelines of 1931, perhaps the first …

In the developed world, biomedical and public health research during the 20th century
resulted in dramatic changes in maternal and infant mortality rates, the near eradication of …