DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

R Abbassi, TG Johns, M Kassiou, L Munoz - Pharmacology & therapeutics, 2015 - Elsevier
Protein kinases are one of the most studied drug targets in current pharmacological
research, as evidenced by the vast number of kinase-targeting agents enrolled in active …

Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitors as potential therapeutics

DB Jarhad, KK Mashelkar, HR Kim… - Journal of medicinal …, 2018 - ACS Publications
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is a member of an
evolutionarily conserved family of protein kinases that belongs to the CMGC group of …

DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis

P Fernandez-Martinez, C Zahonero… - Molecular & cellular …, 2015 - Taylor & Francis
DYRK1A (dual-specificity tyrosine-regulated kinase 1A) is a kinase with multiple implications
for embryonic development, especially in the nervous system where it regulates the balance …

Activation, regulation, and inhibition of DYRK1A

W Becker, W Sippl - The FEBS journal, 2011 - Wiley Online Library
Dual‐specificity tyrosine phosphorylation‐regulated kinase 1A (DYRK1A) is a protein kinase
with diverse functions in neuronal development and adult brain physiology. Higher than …

DYRK1A kinase inhibition with emphasis on neurodegeneration: A comprehensive evolution story-cum-perspective

A Pathak, A Rohilla, T Gupta, MJ Akhtar… - European Journal of …, 2018 - Elsevier
Alzheimer, the fourth leading cause of death embodies a key responsible event including
formation of β-amyloid protein clustering to amyloid plaque on blood vessels. The origin of …

DYRK1A kinase inhibitors with emphasis on cancer

A Ionescu, F Dufrasne, M Gelbcke… - Mini reviews in …, 2012 - ingentaconnect.com
Various types of cancers (including gliomas, melanomas, and esophageal, pancreas and
non-small-cell lung cancers) display intrinsic resistance to pro-apoptotic stimuli, such as …

Fragment-derived selective inhibitors of dual-specificity kinases DYRK1A and DYRK1B

D Lee Walmsley, JB Murray, P Dokurno… - Journal of medicinal …, 2021 - ACS Publications
The serine/threonine kinase DYRK1A has been implicated in regulation of a variety of
cellular processes associated with cancer progression, including cell cycle control, DNA …

Function and inhibition of DYRK1A: emerging roles of treating multiple human diseases

Y Yang, X Fan, Y Liu, D Ye, C Liu, H Yang, Z Su… - Biochemical …, 2023 - Elsevier
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) is an evolutionarily
conserved protein kinase and the most studied member of the Dual-specificity tyrosine …

DYRK1A inhibitors for disease therapy: Current status and perspectives

T Liu, Y Wang, J Wang, C Ren, H Chen… - European journal of …, 2022 - Elsevier
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a conserved
protein kinase that plays essential roles in various biological processes. It is located in the …

The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target

M Rammohan, E Harris, RS Bhansali, E Zhao, LS Li… - Oncogene, 2022 - nature.com
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …