Creating permissive microenvironments for stem cell transplantation into the central nervous system

H Kim, MJ Cooke, MS Shoichet - Trends in biotechnology, 2012 - cell.com
Traumatic injury to the central nervous system (CNS) is highly debilitating, with the clinical
need for regenerative therapies apparent. Neural stem/progenitor cells (NSPCs) are …

Biomaterial strategies to bolster neural stem cell-mediated repair of the central nervous system

G Tejeda, AJ Ciciriello, CM Dumont - Cells Tissues Organs, 2023 - karger.com
Stem cell therapies have the potential to not only repair, but to regenerate tissue of the
central nervous system (CNS). Recent studies demonstrate that transplanted stem cells can …

Endogenous and exogenous CNS derived stem/progenitor cell approaches for neurotrauma

I Kulbatski, AJ Mothe, H Nomura… - Current drug targets, 2005 - ingentaconnect.com
Neural stem/progenitor cells capable of generating new neurons and glia, reside in specific
areas of the adult mammalian central nervous system (CNS), including the ependymal …

Matrices, scaffolds & carriers for cell delivery in nerve regeneration

ZZ Wang, SE Sakiyama-Elbert - Experimental neurology, 2019 - Elsevier
Nerve injuries can be life-long debilitating traumas that severely impact patients' quality of
life. While many acellular neural scaffolds have been developed to aid the process of nerve …

[HTML][HTML] Improvements in biomaterial matrices for neural precursor cell transplantation

NB Skop, F Calderon, CH Cho, CD Gandhi… - Molecular and cellular …, 2014 - Springer
Progress is being made in developing neuroprotective strategies for traumatic brain injuries;
however, there will never be a therapy that will fully preserve neurons that are injured from …

Experimental therapies for repair of the central nervous system: stem cells and tissue engineering

N Forraz, KE Wright, M Jurga… - Journal of tissue …, 2013 - Wiley Online Library
Several stem cell‐based therapeutic tools are currently being investigated for the
regeneration of central nervous system (CNS) injuries. This review focuses on innovative …

Engineering the CNS stem cell microenvironment

CA Williams, EB Lavik - Regenerative medicine, 2009 - Taylor & Francis
The loss of neural tissue underlies the symptomatology of several neurological insults of
disparate etiology, including trauma, cerebrovascular insult and neurodegenerative disease …

In vitro neural injury model for optimization of tissue‐engineered constructs

DK Cullen, SE Stabenfeldt, CM Simon… - Journal of …, 2007 - Wiley Online Library
Stem cell transplantation is a promising approach for the treatment of traumatic brain injury,
although the therapeutic benefits are limited by a high degree of donor cell death. Tissue …

[HTML][HTML] Regenerative therapies for central nervous system diseases: a biomaterials approach

RY Tam, T Fuehrmann, N Mitrousis… - …, 2014 - nature.com
The central nervous system (CNS) has a limited capacity to spontaneously regenerate
following traumatic injury or disease, requiring innovative strategies to promote tissue and …

Design of biomaterials to enhance stem cell survival when transplanted into the damaged central nervous system

MJ Cooke, K Vulic, MS Shoichet - Soft Matter, 2010 - pubs.rsc.org
Following injury to the central nervous system (CNS) there is a cascade of events that leads
to cell death, tissue loss and consequently functional deficit. In response to injury, the CNS …