Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …

The ability to predict hepatic metabolic clearance is a key component in the design and
selection of small molecule drug candidates within the pharmaceutical industry. The …

Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …

Recent studies of membrane transporters have revealed their importance in determining the
pharmacokinetics of transporter substrates. When drug-drug interactions (DDIs) or genetic …

Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …

Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …

To assess the feasibility of using sandwich-cultured human hepatocytes (SCHHs) as a
model to characterize transport kinetics for in vivo pharmacokinetic prediction, the …

Hepatic drug transporters can play an important role in pharmacokinetics and the disposition
of therapeutic drugs and endogenous substances. Altered function of hepatic drug …

Increasing challenges include the application of in vitro/in vivo models for prediction of
safety and pharmacokinetic profiles for the compounds entering drug development that are …

Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …