No Heading The Biopharmaceutics Classification System (BCS) was developed to allow
prediction of in vivo pharmacokinetic performance of drug products from measurements of …

The role of membrane transporters on pharmacokinetics (PKs), drug–drug interactions
(DDIs), pharmacodynamics (PDs), and toxicity of drugs has been broadly recognized …

Recent analyses demonstrated that metabolites are unlikely to contribute significantly to
clinical inhibition of cytochrome P450 (P450)–mediated drug metabolism, and that only∼ …

Comprehensive characterization of transporter mediated drug‐drug interactions (DDIs) is
important to formulate clinical management strategies and ensure the safe and effective use …

Transporters play an important role in drug absorption, disposition, and drug action. The
evaluation of drug transporters requires a comprehensive understanding of transporter …

Due to its implications for both dose level and frequency, clearance rate is one of the most
important pharmacokinetic parameters to consider in the design of drug candidates …

Active transport across biological membranes represents a critical step in the disposition of
many drugs. It is now well-established that different efflux and uptake transporters such as P …

It has been well accepted that hepatic drug extraction depends on the blood flow, vascular
binding, transmembrane barriers, transporters, enzymes and cosubstrate and their zonal …

We have seen an increased use of computational approaches to predicting drug interactions
with human transporters that affect drug disposition and may lead to toxicity. These …

The importance of drug transporters as one of the determinants of pharmacokinetics has
become increasingly evident [1]. While much research has been conducted focusing the role …