Background Epigenetic clocks based on DNA methylation yield high correlations with
chronological age in cross-sectional data. Due to a paucity of longitudinal data, it is not …

Epigenetic changes during ageing have been characterized by multiple epigenetic clocks
that allow the prediction of chronological age based on methylation status. Despite their …

Background The trajectory of frailty in older adults is important to public health; therefore,
markers that may help predict this and other important outcomes could be beneficial …

Age-associated DNA methylation changes have been widely reported across many different
tissue and cell types. Epigenetic 'clocks' that can predict chronological age with a …

All humans age, but how we age—and how fast—differs considerably from person to
person. This deviation between apparent age and chronological age is often referred to as …

Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …

Human DNA methylation data have been used to develop biomarkers of ageing, referred to
as 'epigenetic clocks', which have been widely used to identify differences between …

Background Epigenetic clocks are promising tools for the study of aging in humans. The
clocks quantify biological aging above and beyond chronological age, demonstrate …

Identifying and validating molecular targets of interventions that extend the human health
span and lifespan has been difficult, as most clinical biomarkers are not sufficiently …

The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …