L Lyu, Z Chen, N McCarty - Autophagy, 2022 - Taylor & Francis
Until recently, the ubiquitin-proteasome system (UPS) and macroautophagy/autophagy were considered to be two independent systems that target proteins for degradation by …
Sequestration of protein aggregates in inclusion bodies and their subsequent degradation prevents proteostasis imbalance, cytotoxicity, and proteinopathies. The underlying …
M Ganassi, D Mateju, I Bigi, L Mediani, I Poser, HO Lee… - Molecular cell, 2016 - cell.com
Stress granules (SGs) are ribonucleoprotein complexes induced by stress. They sequester mRNAs and disassemble when the stress subsides, allowing translation restoration. In …
ABSTRACT TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces …
T Han, M Guo, M Gan, B Yu, X Tian, JB Wang - Autophagy, 2018 - Taylor & Francis
Macroautophagy/autophagy is a multistep cellular process that sequesters cytoplasmic components for lysosomal degradation. BECN1/Beclin1 is a central protein that assembles …
L Vu, A Ghosh, C Tran, WA Tebung… - Journal of proteome …, 2021 - ACS Publications
Cytoplasmic stress granules (SGs) are dynamic foci containing translationally arrested mRNA and RNA-binding proteins (RBPs) that form in response to a variety of cellular …
A Turakhiya, SR Meyer, G Marincola, S Böhm… - Molecular cell, 2018 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of mRNPs stalled in translation initiation. They are induced by various stress conditions, including exposure to the environmental …
JA Pan, Y Sun, YP Jiang, AJ Bott, N Jaber, Z Dou… - Molecular cell, 2016 - cell.com
TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose expression is elevated in autoimmune disease. While TRIM21 plays an important role in immune …
SJ Seguin, FF Morelli, J Vinet, D Amore… - Cell Death & …, 2014 - nature.com
Stress granules (SGs) are mRNA-protein aggregates induced during stress, which accumulate in many neurodegenerative diseases. Previously, the autophagy-lysosome …